Detail publikace

Tensegrity finite element models of mechanical tests of individual cells

BURŠA, J. HOLATA, J. LEBIŠ, R.

Originální název

Tensegrity finite element models of mechanical tests of individual cells

Typ

článek v časopise - ostatní, Jost

Jazyk

angličtina

Originální abstrakt

A three-dimensional finite element model of a vascular smooth muscle cell is based on models published recently; it comprehends elements representing cell membrane, cytoplasm and nucleus, and a complex tensegrity structure representing the cytoskeleton. In contrast to previous models of eucaryotic cells, this tensegrity structure consists of several parts. Its external and internal parts number 30 struts, 60 cables each, and their nodes are interconnected by 30 radial members; these parts represent cortical, nuclear and deep cytoskeletons, respectively. This arrangement enables us to simulate load transmission from the extracellular space to the nucleus or centrosome via membrane receptors (focal adhesions); the ability of the model was tested by simulation of some mechanical tests with isolated vascular smooth muscle cells. Although material properties of components defined on the basis of the mechanical tests are ambiguous, modelling of different types of tests has shown the ability of the model to simulate substantial global features of cell behaviour, e.g. action at a distance effect or the global load-deformation response of the cell under various types of loading. Based on computational simulations, the authors offer a hypothesis explaining the scatter of experimental results of indentation tests.

Klíčová slova

Cell biomechanics; Tensegrity structure; Cytoskeleton; Computational model

Autoři

BURŠA, J.; HOLATA, J.; LEBIŠ, R.

Rok RIV

2012

Vydáno

16. 4. 2012

Nakladatel

Elsevier Science B.V.

Místo

Amsterdam

ISSN

0928-7329

Periodikum

Technology and Health Care, Int. Journal of Health Care Engineering

Ročník

20

Číslo

2

Stát

Nizozemsko

Strany od

135

Strany do

150

Strany počet

16

BibTex

@article{BUT88700,
  author="Jiří {Burša} and Jakub {Holata} and Radek {Lebiš}",
  title="Tensegrity finite element models of mechanical tests of individual cells",
  journal="Technology and Health Care, Int. Journal of Health Care Engineering",
  year="2012",
  volume="20",
  number="2",
  pages="135--150",
  issn="0928-7329"
}