Detail publikace

Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours

KREJČOVÁ, L. FABRIK, I. HYNEK, D. KŘÍŽKOVÁ, S. GUMULEC, J. VACULOVIČOVÁ, M. ADAM, V. BABULA, P. TRNKOVÁ, L. STIBOROVÁ, M. HUBÁLEK, J. MASAŘÍK, M. BINKOVÁ, H. ECKSCHLAGER, T. KIZEK, R.

Originální název

Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

There are more than half of million patients who fall ill with head and neck carcinoma per year, which 6 % of annually newly diagnosed malignant diseases in the world. The most important objective of this study is the electrochemical monitoring of metallothionein levels in patients with primary malignant tumors in head and neck examination and the suitability of electrochemical detection as a technique used in clinical practice. In conclusion, MT levels are closely associated with the rate of tumour differentiation, stage of tumour disease and tumour cell characteristics. Our study demonstrates not only changes in blood MT levels in patients suffering from malignant tumour disease in head and neck area, but also suitability of electrochemical techniques for blood analysis.

Klíčová slova

electrochemical detection; head and neck cancer; voltammetry; catalytic signal; metallothionein; marker

Autoři

KREJČOVÁ, L.; FABRIK, I.; HYNEK, D.; KŘÍŽKOVÁ, S.; GUMULEC, J.; VACULOVIČOVÁ, M.; ADAM, V.; BABULA, P.; TRNKOVÁ, L.; STIBOROVÁ, M.; HUBÁLEK, J.; MASAŘÍK, M.; BINKOVÁ, H.; ECKSCHLAGER, T.; KIZEK, R.

Rok RIV

2012

Vydáno

1. 3. 2012

ISSN

1452-3981

Periodikum

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

Ročník

7

Číslo

3

Stát

Srbská republika

Strany od

1767

Strany do

1784

Strany počet

18

BibTex

@article{BUT90342,
  author="Ludmila {Krejčová} and Ivo {Fabrik} and David {Hynek} and Soňa {Křížková} and Jaromír {Gumulec} and Markéta {Vaculovičová} and Vojtěch {Adam} and Petr {Babula} and Libuše {Trnková} and Marie {Stiborová} and Jaromír {Hubálek} and Michal {Masařík} and Hana {Binková} and Tomáš {Eckschlager} and René {Kizek}",
  title="Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours",
  journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE",
  year="2012",
  volume="7",
  number="3",
  pages="1767--1784",
  issn="1452-3981"
}