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LÍZAL, F. FUSEK, M. JEDELSKÝ, J. JÍCHA, M.
Originální název
Application of statistical methods in human airway flow analysis
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
angličtina
Originální abstrakt
Understanding of the air flow in human airways is the cornerstone for targeted delivery of a medication to the lungs. Direct in-vivo measurement in lungs is complicated; therefore in-vitro measurements in human lung models are frequently performed employing optical measurement methods. Irregularly sampled data acquired by Phase Doppler Anemometry in various locations of a model of human lungs for different breathing conditions were statistically processed to facilitate comparison and influence of diverse factors on the lung airflow. Tests based on signs of differences, Kendall s rank correlation coefficient test and Spearman s rank correlation coefficient test were used to detect a linear trend between the samples,while a median test of randomness and a turning point test were used to detect differences of a periodical nature. The presented statistical tools allow detection of inter-cycle variability in velocity course as well as evaluation of the influence of breathing pattern change or gradual flow development in an airway. Application of the above mentioned methods on our data confirmed the essential influence of lung geometry on flow profiles and revealed remarkable flow behaviour in the main bronchi. Usability of the statistical tools is not limited to measurements in human lung models, but can be extended to any flow measurements, for comparison of irregularly and regularly sampled data and also for comparison of numerical simulations with experiments.
Klíčová slova
flow analysis, human airways, lung flow, statistical analysis, airflow measurement.
Autoři
LÍZAL, F.; FUSEK, M.; JEDELSKÝ, J.; JÍCHA, M.
Rok RIV
2012
Vydáno
25. 6. 2012
Nakladatel
WIT Press
Místo
Ashurst, Southampton, UK
ISBN
9781845646004
Kniha
9th International Conference on Advances in Fluid Mechanics - Advances in Fluid Mechanics IX
ISSN
1743-3533
Periodikum
WIT Transactions on Engineering Sciences
Ročník
74
Číslo
2
Stát
Spojené království Velké Británie a Severního Irska
Strany od
571
Strany do
583
Strany počet
13
BibTex
@inproceedings{BUT92801, author="František {Lízal} and Michal {Fusek} and Jan {Jedelský} and Miroslav {Jícha}", title="Application of statistical methods in human airway flow analysis", booktitle="9th International Conference on Advances in Fluid Mechanics - Advances in Fluid Mechanics IX", year="2012", journal="WIT Transactions on Engineering Sciences", volume="74", number="2", pages="571--583", publisher="WIT Press", address="Ashurst, Southampton, UK", doi="10.2495/AFM120491", isbn="9781845646004", issn="1743-3533" }