Project detail

Investigating protein-gold nanoparticles interaction using laser ablation

Duration: 01.03.2020 — 28.02.2021

Funding resources

Brno University of Technology - Vnitřní projekty VUT

- whole funder (2020-01-01 - 2021-12-31)

On the project

After entering the blood stream, NPs are immediately covered by hundreds of plasma proteins. This is the reason why NPs based methods of drug delivery show good results in vitro but struggle in vivo. To avoid this problem, the protein corona can be formed in advance on the NPs surface. The aim of this project is to examine the completely new approach to corona formation detection using laser ablation and bring better understanding of the interaction between the laser and the NPs-protein system.

Mark

CEITEC VUT-J-20-6350

Default language

Czech

People responsible

Kaiser Jozef, prof. Ing., Ph.D. - fellow researcher
Salajková Zita, Ing., Ph.D. - principal person responsible

Units

Advanced instrumentation and methods for material characterization
- (2020-01-01 - 2020-12-31)
Central European Institute of Technology BUT
- (2020-01-01 - 2020-12-31)

Results

SALAJKOVÁ, Z.; HOLÁ, M.; PROCHAZKA, D.; ONDRAČEK, J.; PAVLIŇÁK, D.; ČELKO, L.; GREGAR, F.; ŠPERKA, P.; POŘÍZKA, P.; KANICKÝ, V.; DE GIACOMO, A.; KAISER, J. Influence of sample surface topography on laser ablation process. Talanta, 2021, vol. 222, no. 121512, p. 1-9. ISSN: 0039-9140.
Detail

SALAJKOVÁ, Z.; HOLÁ, M.; PROCHAZKA, D.; POŘÍZKA, P.; DE GIACOMO, A.; KAISER, J. Effect of sample surface treatment on Laser Ablation. Kyoto, Japan: LIBS2020, 2020.
Detail

DELL'AGLIO, M.; SALAJKOVÁ, Z.; MALLARDI, A.; SPORTELLI, M.;KAISER, J.; CIOFFI, N.; DE GIACOMO, A. Sensing nanoparticle-protein corona using nanoparticle enhanced Laser Induced Breakdown Spectroscopy signal enhancement. Talanta, 2021, vol. 235, no. 122741, p. 1-8. ISSN: 0039-9140.
Detail

HOLÁ, M.; SALAJKOVÁ, Z.; HRDLIČKA, A.; ONDRÁČEK, J.; NOVOTNÝ, K.; PAVLIŇÁK, D.; VOJTÍŠEK-LOM, M.; ČELKO, L.; POŘÍZKA, P.; KANICKÝ, V.; PROCHAZKA, D.; NOVOTNÝ, J.; KAISER, J. The effect of nanoparticle presence on aerosol formation during nanoparticle-enhanced laser ablation inductively coupled plasma mass spectrometry. Journal of Analytical Atomic Spectrometry, 2020, vol. 35, no. 12, p. 2893-2900. ISSN: 1364-5544.
Detail

Marcella Dell'Aglio, Zita Salajkova, Antonia Mallardi, Raffaele Mezzenga, Leonie Van't Hag, Nicola Cioffi, Gerardo Palazzo, Alessandro De Giacomo. Application of gold nanoparticles embedded in the amyloids fibrils as enhancers in the laser induced breakdown spectroscopy for the metal quantification in microdroplets. Sparks, USA: SciX2020, 2020.
Detail

Responsibility: Salajková Zita, Ing., Ph.D.