Project detail

Faraday’s Scalpel: electrochemical oxygen reduction for precise neural tissue ablation

Duration: 01.01.2023 — 31.12.2025

Funding resources

Czech Science Foundation - Standardní projekty

- whole funder

On the project

We propose a novel concept of a “Faraday’s scalpel”: an approach to deoxygenate brain tissue using electrocatalytic oxygen reduction and direct electrical currents. The hypothesis is that local hypoxia induced by the Faraday Scalpel electrode will selectively destroy neurons while preserving other cells, opening new possibilities for precise electrosurgery for conditions like epilepsy. This proposal has three objectives: A) optimize two types of faradaic electrodes: one for hypoxia, and another for hypoxia plus hydrogen peroxide generation; B) develop multifunctional electronic/optical implantable probes to deoxygenate tissue while allowing in situ characterization of oxygen level, tissue morphology, and electrophysiology. C) apply the concept in vivo to achieve hypoxic ablation, validated by measuring neural activity and optical/histological methods. The project is interdisciplinary, covering electrochemistry, microelectronics, physiology, and advanced optical imaging. Success of our project will create powerful tools for basic research and a promising approach for neurosurgery.

Keywords
bioelectronics;electrochemistry;reactive oxygen species;oxygen reduction reaction; electrophysiology

Mark

23-07432S

Default language

English

People responsible

Glowacki Eric Daniel, prof., Ph.D. - principal person responsible

Units

Bioelectronics Materials and Systems
- beneficiary (2023-01-01 - 2026-12-31)
Central European Institute of Technology BUT
- responsible department (2022-03-31 - 2022-03-31)

Results

MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E. Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry. Chembiochem : a European journal of chemical biology, 2023, vol. 24, no. 17, p. 1-14. ISSN: 1439-7633.
Detail

JAKEŠOVÁ, M.; KUNOVSKÝ, O.; GABLECH, I.; KHODAGHOLY, D.; GELINAS, J.; GLOWACKI, E. Coupling of photovoltaics with neurostimulation electrodes-optical to electrolytic transduction. Journal of Neural Engineering, 2024, vol. 21, no. 4, ISSN: 1741-2552.
Detail

GRYSZEL, M.; JAKEŠOVÁ, M.; VU, X.; INGEBRANDT, S.; GLOWACKI, E. Elevating Platinum to Volumetric Capacitance: High Surface Area Electrodes through Reactive Pt Sputtering. Advanced Healthcare Materials, 2024, vol. 13, no. 5, ISSN: 2192-2640.
Detail

GABLECH, I.; GLOWACKI, E. State-of-the-Art Electronic Materials for Thin Films in Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 8, p. 1-23. ISSN: 2199-160X.
Detail

Responsibility: Glowacki Eric Daniel, prof., Ph.D.