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Detail projektu
Období řešení: 01.01.2023 — 31.12.2025
Zdroje financování
Grantová agentura České republiky - Standardní projekty
- plně financující
O projektu
We propose a novel concept of a “Faraday’s scalpel”: an approach to deoxygenate brain tissue using electrocatalytic oxygen reduction and direct electrical currents. The hypothesis is that local hypoxia induced by the Faraday Scalpel electrode will selectively destroy neurons while preserving other cells, opening new possibilities for precise electrosurgery for conditions like epilepsy. This proposal has three objectives: A) optimize two types of faradaic electrodes: one for hypoxia, and another for hypoxia plus hydrogen peroxide generation; B) develop multifunctional electronic/optical implantable probes to deoxygenate tissue while allowing in situ characterization of oxygen level, tissue morphology, and electrophysiology. C) apply the concept in vivo to achieve hypoxic ablation, validated by measuring neural activity and optical/histological methods. The project is interdisciplinary, covering electrochemistry, microelectronics, physiology, and advanced optical imaging. Success of our project will create powerful tools for basic research and a promising approach for neurosurgery.
Klíčová slovabioelectronics;electrochemistry;reactive oxygen species;oxygen reduction reaction; electrophysiology
Označení
23-07432S
Originální jazyk
angličtina
Řešitelé
Glowacki Eric Daniel, prof., Ph.D. - hlavní řešitel
Útvary
Bioelektronické materiály a systémy- příjemce (01.01.2023 - 31.12.2026)Středoevropský technologický institut VUT- odpovědné pracoviště (31.03.2022 - 31.03.2022)
Výsledky
GABLECH, I.; GLOWACKI, E. State-of-the-Art Electronic Materials for Thin Films in Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 8, p. 1-23. ISSN: 2199-160X.Detail
MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E. Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry. Chembiochem : a European journal of chemical biology, 2023, vol. 24, no. 17, p. 1-14. ISSN: 1439-7633.Detail