Publication detail

Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins

RUTTKAY-NEDECKÝ, B. JIMENEZ JIMENEZ, A. NEJDL, L. CHUDOBOVÁ, D. GUMULEC, J. MASAŘÍK, M. ADAM, V. KIZEK, R.

Original Title

Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins

Type

journal article in Web of Science

Language

English

Original Abstract

Human papillomaviruses (HPV) are small circular, double-stranded DNA viruses infecting epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than 120 different identified types of HPV, the majority are involved in infections of the genital tract, cancer of the cervix, vulva, vagina and penis, and of non-anogenital localizations, such as the head and neck areas. From the point of view of the infection, human papillomaviruses have developed several molecular mechanisms to enable infected cells to suppress apoptosis. This review provides a comprehensive and critical summary of the current literature that focuses on cervical carcinoma and cancer of the head and neck caused by HPV

Keywords

papillomaviruses, cancer of the cervix, infection, molecular mechanisms

Authors

RUTTKAY-NEDECKÝ, B.; JIMENEZ JIMENEZ, A.; NEJDL, L.; CHUDOBOVÁ, D.; GUMULEC, J.; MASAŘÍK, M.; ADAM, V.; KIZEK, R.

RIV year

2013

Released

1. 12. 2013

ISBN

1019-6439

Periodical

INTERNATIONAL JOURNAL OF ONCOLOGY

Year of study

43

Number

6

State

Hellenic Republic

Pages from

1754

Pages to

1762

Pages count

9

BibTex

@article{BUT101244,
  author="Branislav {Ruttkay-Nedecký} and Ana Maria {Jimenez Jimenez} and Lukáš {Nejdl} and Dagmar {Hegerová} and Jaromír {Gumulec} and Michal {Masařík} and Vojtěch {Adam} and René {Kizek}",
  title="Relevance of infection with human papillomavirus: The role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins",
  journal="INTERNATIONAL JOURNAL OF ONCOLOGY",
  year="2013",
  volume="43",
  number="6",
  pages="1754--1762",
  doi="10.3892/ijo.2013.2105",
  issn="1019-6439"
}