Publication detail

Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis

GUMULEC, J. RAUDENSKÁ, M. ADAM, V. KIZEK, R. MASAŘÍK, M.

Original Title

Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis

Type

journal article in Web of Science

Language

English

Original Abstract

Metallothionein (MT) has been extensively investigated as a molecular marker of various types of cancer. In spite of the fact that numerous reviews have been published in this field, no meta-analytical approach has been performed. Therefore, results of to-date immunohistochemistry-based studies were summarized using meta-analysis in this review. Web of science, PubMed, Embase and CENTRAL databases were searched (up to April 30, 2013) and the eligibility of individual studies and heterogeneity among the studies was assessed. Random and fixed effects model meta-analysis was employed depending on the heterogeneity, and publication bias was evaluated using funnel plots and Eggers tests. A total of 77 studies were included with 8,015 tissue samples (4,631 cases and 3,384 controls). A significantly positive association between MT staining and tumors (vs. healthy tissues) was observed in head and neck (odds ratio, OR 9.95; 95% CI 5.82– 17.03) and ovarian tumors (OR 7.83; 1.09–56.29), and a negative association was ascertained in liver tumors (OR 0.10; 0.03–0.30). No significant associations were identified in breast, colorectal, prostate, thyroid, stomach, bladder, kidney, gallbladder, and uterine cancers and in melanoma. . However, a high degree of inconsistence was observed in several tumor types, including colorectal, kidney and prostate cancer. Despite the ambiguity in some tumor types, conclusive results are provided in the tumors of head and neck, ovary and liver and in relation to the tumor grade and patient survival.

Keywords

heterogeneity, imunohistochemistry, Metalothionein

Authors

GUMULEC, J.; RAUDENSKÁ, M.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

RIV year

2014

Released

8. 1. 2014

Publisher

PLOS

ISBN

1932-6203

Periodical

PLOS ONE

Year of study

9

Number

1

State

United States of America

Pages from

1

Pages to

14

Pages count

14

URL

http://europepmc.org/articles/PMC3885711?pdf=render

Full text in the Digital Library

http://hdl.handle.net/11012/63715

BibTex

@article{BUT106200,
  author="Jaromír {Gumulec} and Martina {Raudenská} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis",
  journal="PLOS ONE",
  year="2014",
  volume="9",
  number="1",
  pages="1--14",
  doi="10.1371/journal.pone.0085346",
  issn="1932-6203",
  url="http://europepmc.org/articles/PMC3885711?pdf=render"
}