Detail publikace

Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis

GUMULEC, J. RAUDENSKÁ, M. ADAM, V. KIZEK, R. MASAŘÍK, M.

Originální název

Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Metallothionein (MT) has been extensively investigated as a molecular marker of various types of cancer. In spite of the fact that numerous reviews have been published in this field, no meta-analytical approach has been performed. Therefore, results of to-date immunohistochemistry-based studies were summarized using meta-analysis in this review. Web of science, PubMed, Embase and CENTRAL databases were searched (up to April 30, 2013) and the eligibility of individual studies and heterogeneity among the studies was assessed. Random and fixed effects model meta-analysis was employed depending on the heterogeneity, and publication bias was evaluated using funnel plots and Eggers tests. A total of 77 studies were included with 8,015 tissue samples (4,631 cases and 3,384 controls). A significantly positive association between MT staining and tumors (vs. healthy tissues) was observed in head and neck (odds ratio, OR 9.95; 95% CI 5.82– 17.03) and ovarian tumors (OR 7.83; 1.09–56.29), and a negative association was ascertained in liver tumors (OR 0.10; 0.03–0.30). No significant associations were identified in breast, colorectal, prostate, thyroid, stomach, bladder, kidney, gallbladder, and uterine cancers and in melanoma. . However, a high degree of inconsistence was observed in several tumor types, including colorectal, kidney and prostate cancer. Despite the ambiguity in some tumor types, conclusive results are provided in the tumors of head and neck, ovary and liver and in relation to the tumor grade and patient survival.

Klíčová slova

heterogeneity, imunohistochemistry, Metalothionein

Autoři

GUMULEC, J.; RAUDENSKÁ, M.; ADAM, V.; KIZEK, R.; MASAŘÍK, M.

Rok RIV

2014

Vydáno

8. 1. 2014

Nakladatel

PLOS

ISSN

1932-6203

Periodikum

PLOS ONE

Ročník

9

Číslo

1

Stát

Spojené státy americké

Strany od

1

Strany do

14

Strany počet

14

URL

http://europepmc.org/articles/PMC3885711?pdf=render

Plný text v Digitální knihovně

http://hdl.handle.net/11012/63715

BibTex

@article{BUT106200,
  author="Jaromír {Gumulec} and Martina {Raudenská} and Vojtěch {Adam} and René {Kizek} and Michal {Masařík}",
  title="Metallothionein – Immunohistochemical Cancer Biomarker: A Meta-Analysis",
  journal="PLOS ONE",
  year="2014",
  volume="9",
  number="1",
  pages="1--14",
  doi="10.1371/journal.pone.0085346",
  issn="1932-6203",
  url="http://europepmc.org/articles/PMC3885711?pdf=render"
}