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HEGER, Z. MERLOS RODRIGO, M. KŘÍŽKOVÁ, S. ZÍTKA, O. BEKLOVÁ, M. KIZEK, R. ADAM, V.
Original Title
Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)
Type
journal article in Web of Science
Language
English
Original Abstract
Estrogen receptors [ERs (subtypes alfa and beta)], classified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepressors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ER alfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influence on the selection of appropriate therapy, as ER positive tumors demonstrate a positive response to hormonal therapy.
Keywords
matrix assisted laser desorption/ionization time of flight, estrogen receptor, estrogen response element, cancer
Authors
HEGER, Z.; MERLOS RODRIGO, M.; KŘÍŽKOVÁ, S.; ZÍTKA, O.; BEKLOVÁ, M.; KIZEK, R.; ADAM, V.
RIV year
2014
Released
1. 5. 2014
ISBN
1792-1082
Periodical
Oncology Letters
Year of study
7
Number
5
State
Hellenic Republic
Pages from
1341
Pages to
1344
Pages count
4
BibTex
@article{BUT106909, author="Zbyněk {Heger} and Miguel Ángel {Merlos Rodrigo} and Soňa {Křížková} and Ondřej {Zítka} and Miroslava {Beklová} and René {Kizek} and Vojtěch {Adam}", title="Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)", journal="Oncology Letters", year="2014", volume="7", number="5", pages="1341--1344", doi="10.3892/ol.2014.1912", issn="1792-1082" }