Publication detail

Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)

HEGER, Z. MERLOS RODRIGO, M. KŘÍŽKOVÁ, S. ZÍTKA, O. BEKLOVÁ, M. KIZEK, R. ADAM, V.

Original Title

Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)

Type

journal article in Web of Science

Language

English

Original Abstract

Estrogen receptors [ERs (subtypes alfa and beta)], classified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepressors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ER alfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influence on the selection of appropriate therapy, as ER positive tumors demonstrate a positive response to hormonal therapy.

Keywords

matrix assisted laser desorption/ionization time of flight, estrogen receptor, estrogen response element, cancer

Authors

HEGER, Z.; MERLOS RODRIGO, M.; KŘÍŽKOVÁ, S.; ZÍTKA, O.; BEKLOVÁ, M.; KIZEK, R.; ADAM, V.

RIV year

2014

Released

1. 5. 2014

ISBN

1792-1082

Periodical

Oncology Letters

Year of study

7

Number

5

State

Hellenic Republic

Pages from

1341

Pages to

1344

Pages count

4

BibTex

@article{BUT106909,
  author="Zbyněk {Heger} and Miguel Ángel {Merlos Rodrigo} and Soňa {Křížková} and Ondřej {Zítka} and Miroslava {Beklová} and René {Kizek} and Vojtěch {Adam}",
  title="Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)",
  journal="Oncology Letters",
  year="2014",
  volume="7",
  number="5",
  pages="1341--1344",
  doi="10.3892/ol.2014.1912",
  issn="1792-1082"
}