Detail publikace

Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)

HEGER, Z. MERLOS RODRIGO, M. KŘÍŽKOVÁ, S. ZÍTKA, O. BEKLOVÁ, M. KIZEK, R. ADAM, V.

Originální název

Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Estrogen receptors [ERs (subtypes alfa and beta)], classified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepressors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ER alfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influence on the selection of appropriate therapy, as ER positive tumors demonstrate a positive response to hormonal therapy.

Klíčová slova

matrix assisted laser desorption/ionization time of flight, estrogen receptor, estrogen response element, cancer

Autoři

HEGER, Z.; MERLOS RODRIGO, M.; KŘÍŽKOVÁ, S.; ZÍTKA, O.; BEKLOVÁ, M.; KIZEK, R.; ADAM, V.

Rok RIV

2014

Vydáno

1. 5. 2014

ISSN

1792-1082

Periodikum

Oncology Letters

Ročník

7

Číslo

5

Stát

Řecká republika

Strany od

1341

Strany do

1344

Strany počet

4

BibTex

@article{BUT106909,
  author="Zbyněk {Heger} and Miguel Ángel {Merlos Rodrigo} and Soňa {Křížková} and Ondřej {Zítka} and Miroslava {Beklová} and René {Kizek} and Vojtěch {Adam}",
  title="Identification of estrogen receptor proteins in breast cancer cells using matrix assisted laser desorption/ionization time of flight mass spectrometry (Review)",
  journal="Oncology Letters",
  year="2014",
  volume="7",
  number="5",
  pages="1341--1344",
  doi="10.3892/ol.2014.1912",
  issn="1792-1082"
}