Přístupnostní navigace
E-application
Search Search Close
Publication detail
KOPEL, P. WAWRZAK, D. LANGER, V. ČÍHALOVÁ, K. CHUDOBOVÁ, D. VESELÝ, R. ADAM, V. KIZEK, R.
Original Title
Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes
Type
journal article in Web of Science
Language
English
Original Abstract
1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) have been further used in combination with trithiocyanuric acid for the preparation of complexes. The crystal and molecular structures of two of them have been solved. Each nickel atom in the structure of trinuclear complex [Ni3(abb)3(H2O)3(μ-ttc)](ClO4)3·3H2O·EtOH (1), where ttcH3 = trithiocyanuric acid, is coordinated with three N atoms of abb, the N,S donor set of ttc anion and an oxygen of a water molecule. The crystal of [(tbbH2)(ttcH2)2(ttcH3)(H2O)] (2) is composed of a protonated bis(benzimidazole), two ttcH2 anions, ttcH3 and water. The structure is stabilized by a network of hydrogen bonds. These compounds were primarily synthesized for their potential antimicrobial activity and hence their possible use in the treatment of infections caused by bacteria or yeasts (fungi). The antimicrobial and antifungal activity of the prepared compounds have been evaluated on a wide spectrum of bacterial and yeast strains and clinical specimens isolated from patients with infectious wounds and the best antimicrobial properties were observed in strains after the use of ligand abb and complex 1, when at least 80% growth inhibition was achieved.
Keywords
coordination compounds; biological activity; trithiocyanuric acid; trimercaptotriazine; single crystal X-ray diffraction; benzimidazole
Authors
KOPEL, P.; WAWRZAK, D.; LANGER, V.; ČÍHALOVÁ, K.; CHUDOBOVÁ, D.; VESELÝ, R.; ADAM, V.; KIZEK, R.
RIV year
2015
Released
1. 6. 2015
Publisher
MDPI
ISBN
1420-3049
Periodical
MOLECULES
Year of study
20
Number
6
State
Swiss Confederation
Pages from
10360
Pages to
10376
Pages count
17
URL
http://www.mdpi.com/1420-3049/20/6/10360
Full text in the Digital Library
http://hdl.handle.net/11012/63724
BibTex
@article{BUT115885, author="Pavel {Kopel} and Dorota {Wawrzak} and Vratislav {Langer} and Kristýna {Číhalová} and Dagmar {Hegerová} and Radek {Veselý} and Vojtěch {Adam} and René {Kizek}", title="Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes", journal="MOLECULES", year="2015", volume="20", number="6", pages="10360--10376", doi="10.3390/molecules200610360", issn="1420-3049", url="http://www.mdpi.com/1420-3049/20/6/10360" }