Detail publikace

Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes

KOPEL, P. WAWRZAK, D. LANGER, V. ČÍHALOVÁ, K. CHUDOBOVÁ, D. VESELÝ, R. ADAM, V. KIZEK, R.

Originální název

Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) have been further used in combination with trithiocyanuric acid for the preparation of complexes. The crystal and molecular structures of two of them have been solved. Each nickel atom in the structure of trinuclear complex [Ni3(abb)3(H2O)3(μ-ttc)](ClO4)3·3H2O·EtOH (1), where ttcH3 = trithiocyanuric acid, is coordinated with three N atoms of abb, the N,S donor set of ttc anion and an oxygen of a water molecule. The crystal of [(tbbH2)(ttcH2)2(ttcH3)(H2O)] (2) is composed of a protonated bis(benzimidazole), two ttcH2 anions, ttcH3 and water. The structure is stabilized by a network of hydrogen bonds. These compounds were primarily synthesized for their potential antimicrobial activity and hence their possible use in the treatment of infections caused by bacteria or yeasts (fungi). The antimicrobial and antifungal activity of the prepared compounds have been evaluated on a wide spectrum of bacterial and yeast strains and clinical specimens isolated from patients with infectious wounds and the best antimicrobial properties were observed in strains after the use of ligand abb and complex 1, when at least 80% growth inhibition was achieved.

Klíčová slova

coordination compounds; biological activity; trithiocyanuric acid; trimercaptotriazine; single crystal X-ray diffraction; benzimidazole

Autoři

KOPEL, P.; WAWRZAK, D.; LANGER, V.; ČÍHALOVÁ, K.; CHUDOBOVÁ, D.; VESELÝ, R.; ADAM, V.; KIZEK, R.

Rok RIV

2015

Vydáno

1. 6. 2015

Nakladatel

MDPI

ISSN

1420-3049

Periodikum

MOLECULES

Ročník

20

Číslo

6

Stát

Švýcarská konfederace

Strany od

10360

Strany do

10376

Strany počet

17

URL

http://www.mdpi.com/1420-3049/20/6/10360

Plný text v Digitální knihovně

http://hdl.handle.net/11012/63724

BibTex

@article{BUT115885,
  author="Pavel {Kopel} and Dorota {Wawrzak} and Vratislav {Langer} and Kristýna {Číhalová} and Dagmar {Hegerová} and Radek {Veselý} and Vojtěch {Adam} and René {Kizek}",
  title="Biological Activity and Molecular Structures of Bis(benzimidazole) and Trithiocyanurate Complexes",
  journal="MOLECULES",
  year="2015",
  volume="20",
  number="6",
  pages="10360--10376",
  doi="10.3390/molecules200610360",
  issn="1420-3049",
  url="http://www.mdpi.com/1420-3049/20/6/10360"
}