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PILGROVÁ, T. PEKAŘ, M. HEJNÁ, J.
Original Title
Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant
Type
conference paper
Language
English
Original Abstract
Physico-chemical interactions in hyaluronan-surfactant system result in nanoparticles formation which can be used in targeted delivery of hydrophobic active substances. The aim of our study was to prepare hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged molecules. Particles were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Size distribution and zeta potential measurement were utilized to explore the formation of complex micelles. Particles size distributions depend on type of solvent, molecular weight of hyaluronan and charge ratio of components of the hyaluronan-surfactant system. Aggregates formation is influenced by preparation of the system. Stability of the micellar particles depends on zeta potential value.
Keywords
hyaluronan, surfactant, nanoparticles, dynamic light scattering, size distribution, zeta potential
Authors
PILGROVÁ, T.; PEKAŘ, M.; HEJNÁ, J.
RIV year
2013
Released
16. 10. 2013
Publisher
TANGER, Ltd., Keltickova 62, 710 00 Ostrava, Czech Republic, EU
Location
Ostrava
ISBN
978-80-87294-47-5
Book
NANOCON 2013 Conference Proceedings
Edition
1st
Pages from
595
Pages to
599
Pages count
6
URL
http://konsys-t.tanger.cz/files/proceedings/14/reports/1926.pdf
BibTex
@inproceedings{BUT127413, author="Tereza {Pilgrová} and Miloslav {Pekař} and Jana {Mourycová}", title="Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant", booktitle="NANOCON 2013 Conference Proceedings", year="2013", series="1st", pages="595--599", publisher="TANGER, Ltd., Keltickova 62, 710 00 Ostrava, Czech Republic, EU", address="Ostrava", isbn="978-80-87294-47-5", url="http://konsys-t.tanger.cz/files/proceedings/14/reports/1926.pdf" }