Publication detail

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

RAUDENSKÁ, M. DVOŘÁKOVÁ, V. PÁCAL, L. CHALÁSOVÁ, K. KRATOCHVÍLOVÁ, M. GUMULEC, J. RUTTKAY-NEDECKÝ, B. ZÍTKA, O. KAŇKOVÁ, K. ADAM, V. MASAŘÍK, M.

Original Title

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Type

journal article in Web of Science

Language

English

Original Abstract

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was asso- ciated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Keywords

diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress

Authors

RAUDENSKÁ, M.; DVOŘÁKOVÁ, V.; PÁCAL, L.; CHALÁSOVÁ, K.; KRATOCHVÍLOVÁ, M.; GUMULEC, J.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; KAŇKOVÁ, K.; ADAM, V.; MASAŘÍK, M.

Released

1. 6. 2017

ISBN

1095-6670

Periodical

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Year of study

31

Number

6

State

United States of America

Pages from

1

Pages to

5

Pages count

5

BibTex

@article{BUT140014,
  author="Martina {Raudenská} and Veronika {Dvořáková} and Lukáš {Pácal} and Katarína {Chalásová} and Monika {Kratochvílová} and Jaromír {Gumulec} and Branislav {Ruttkay-Nedecký} and Ondřej {Zítka} and Kateřina {Kaňková} and Vojtěch {Adam} and Michal {Masařík}",
  title="Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease",
  journal="JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY",
  year="2017",
  volume="31",
  number="6",
  pages="1--5",
  doi="10.1002/jbt.21891",
  issn="1095-6670"
}