Detail publikace

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

RAUDENSKÁ, M. DVOŘÁKOVÁ, V. PÁCAL, L. CHALÁSOVÁ, K. KRATOCHVÍLOVÁ, M. GUMULEC, J. RUTTKAY-NEDECKÝ, B. ZÍTKA, O. KAŇKOVÁ, K. ADAM, V. MASAŘÍK, M.

Originální název

Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hyperglycemia, a major metabolic disturbance present in diabetes, promotes oxidative stress. Activation of antioxidant defense is an important mechanism to prevent cell damage. Levels of heavy metals and their binding proteins can contribute to oxidative stress. Antiradical capacity and levels of metallothionein (MT), metals (zinc and copper), and selected antioxidants (bilirubin, cysteine, and glutathione) were determined in 70 type 2 diabetes mellitus (T2DM) subjects and 80 healthy subjects of Caucasian origin. Single nucleotide polymorphism (rs28366003) in MT gene was detected. Antiradical capacity, conjugated bilirubin, and copper were significantly increased in diabetics, whereas MT and glutathione were decreased. Genotype AA of rs28366003 was asso- ciated with higher zinc levels in the diabetic group. The studied parameters were not influenced by renal function. This is the first study comprehensively investigating differences in MT and metals relevant to oxidative stress in T2DM. Ascertained differences indicate increased oxidative stress in T2DM accompanied by abnormalities in non-enzymatic antioxidant defense systems.

Klíčová slova

diabetes; diabetic kidney disease; heavy metals; metallothionein; oxidative stress

Autoři

RAUDENSKÁ, M.; DVOŘÁKOVÁ, V.; PÁCAL, L.; CHALÁSOVÁ, K.; KRATOCHVÍLOVÁ, M.; GUMULEC, J.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; KAŇKOVÁ, K.; ADAM, V.; MASAŘÍK, M.

Vydáno

1. 6. 2017

ISSN

1095-6670

Periodikum

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Ročník

31

Číslo

6

Stát

Spojené státy americké

Strany od

1

Strany do

5

Strany počet

5

BibTex

@article{BUT140014,
  author="Martina {Raudenská} and Veronika {Dvořáková} and Lukáš {Pácal} and Katarína {Chalásová} and Monika {Kratochvílová} and Jaromír {Gumulec} and Branislav {Ruttkay-Nedecký} and Ondřej {Zítka} and Kateřina {Kaňková} and Vojtěch {Adam} and Michal {Masařík}",
  title="Levels of heavy metals and their binding protein metallothionein in type 2 diabetics with kidney disease",
  journal="JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY",
  year="2017",
  volume="31",
  number="6",
  pages="1--5",
  doi="10.1002/jbt.21891",
  issn="1095-6670"
}