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MICHALICOVÁ, P. MRAVEC, F. PEKAŘ, M.
Original Title
Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species
Type
journal article in Web of Science
Language
English
Original Abstract
A freeze-drying method enabling solubilization of hydrophobic species in aqueous solutions of native hyaluronan is described. The method is based on opening the access to supposed hydrophobic patches on hyaluronan by disturbing its massive hydration shell. Hydrophobic and/or polarity-sensitive fluorescence probes were used as hydrophobic models or indicators of interactions with hydrophobic patches. Fluorescence parameters specific to individual probes confirmed the efficiency of the freeze-drying method. This work is the first step in developing biocompatible and biodegradable carriers for hydrophobic drugs with targeted distribution of the active compound from native, chemically non-modified hyaluronan.
Keywords
fluorescence; freeze-drying; hyaluronan; solubilization
Authors
MICHALICOVÁ, P.; MRAVEC, F.; PEKAŘ, M.
Released
3. 10. 2017
Publisher
PLOS
ISBN
1932-6203
Periodical
PLOS ONE
Year of study
12
Number
9
State
United States of America
Pages from
1
Pages to
13
Pages count
URL
http://europepmc.org/articles/PMC5590968?pdf=render
Full text in the Digital Library
http://hdl.handle.net/11012/84116
BibTex
@article{BUT141013, author="Petra {Michalicová} and Filip {Mravec} and Miloslav {Pekař}", title="Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species", journal="PLOS ONE", year="2017", volume="12", number="9", pages="1--13", doi="10.1371/journal.pone.0184558", issn="1932-6203", url="http://europepmc.org/articles/PMC5590968?pdf=render" }