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MICHALICOVÁ, P. MRAVEC, F. PEKAŘ, M.
Originální název
Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
A freeze-drying method enabling solubilization of hydrophobic species in aqueous solutions of native hyaluronan is described. The method is based on opening the access to supposed hydrophobic patches on hyaluronan by disturbing its massive hydration shell. Hydrophobic and/or polarity-sensitive fluorescence probes were used as hydrophobic models or indicators of interactions with hydrophobic patches. Fluorescence parameters specific to individual probes confirmed the efficiency of the freeze-drying method. This work is the first step in developing biocompatible and biodegradable carriers for hydrophobic drugs with targeted distribution of the active compound from native, chemically non-modified hyaluronan.
Klíčová slova
fluorescence; freeze-drying; hyaluronan; solubilization
Autoři
MICHALICOVÁ, P.; MRAVEC, F.; PEKAŘ, M.
Vydáno
3. 10. 2017
Nakladatel
PLOS
ISSN
1932-6203
Periodikum
PLOS ONE
Ročník
12
Číslo
9
Stát
Spojené státy americké
Strany od
1
Strany do
13
Strany počet
URL
http://europepmc.org/articles/PMC5590968?pdf=render
Plný text v Digitální knihovně
http://hdl.handle.net/11012/84116
BibTex
@article{BUT141013, author="Petra {Michalicová} and Filip {Mravec} and Miloslav {Pekař}", title="Fluorescence study of freeze-drying as a method for support the interactions between hyaluronan and hydrophobic species", journal="PLOS ONE", year="2017", volume="12", number="9", pages="1--13", doi="10.1371/journal.pone.0184558", issn="1932-6203", url="http://europepmc.org/articles/PMC5590968?pdf=render" }