Publication detail

Metallothioneins and zinc in cancer diagnosis and therapy

KŘÍŽKOVÁ, S. VACULOVIČOVÁ, M. HRABĚTA, J. ADAM, V. STIBOROVÁ, M. ECKSCHLAGER, T. KIZEK, R.

Original Title

Metallothioneins and zinc in cancer diagnosis and therapy

Type

journal article in Web of Science

Language

English

Original Abstract

Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn2+ redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in cancer diagnosis and therapy is summarized and their importance for chemoresistance is also mentioned.

Keywords

methallothionein; oxidative stress; cancer diagnosis

Authors

KŘÍŽKOVÁ, S.; VACULOVIČOVÁ, M.; HRABĚTA, J.; ADAM, V.; STIBOROVÁ, M.; ECKSCHLAGER, T.; KIZEK, R.

Released

1. 12. 2012

ISBN

0360-2532

Periodical

DRUG METABOLISM REVIEWS

Year of study

44

Number

4

State

United States of America

Pages from

287

Pages to

301

Pages count

15

BibTex

@article{BUT144330,
  author="Soňa {Křížková} and Markéta {Vaculovičová} and Jan {Hraběta} and Vojtěch {Adam} and Marie {Stiborová} and Tomáš {Eckschlager} and René {Kizek}",
  title="Metallothioneins and zinc in cancer diagnosis and therapy",
  journal="DRUG METABOLISM REVIEWS",
  year="2012",
  volume="44",
  number="4",
  pages="287--301",
  doi="10.3109/03602532.2012.725414",
  issn="0360-2532"
}