Detail publikace

Metallothioneins and zinc in cancer diagnosis and therapy

KŘÍŽKOVÁ, S. VACULOVIČOVÁ, M. HRABĚTA, J. ADAM, V. STIBOROVÁ, M. ECKSCHLAGER, T. KIZEK, R.

Originální název

Metallothioneins and zinc in cancer diagnosis and therapy

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn2+ redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in cancer diagnosis and therapy is summarized and their importance for chemoresistance is also mentioned.

Klíčová slova

methallothionein; oxidative stress; cancer diagnosis

Autoři

KŘÍŽKOVÁ, S.; VACULOVIČOVÁ, M.; HRABĚTA, J.; ADAM, V.; STIBOROVÁ, M.; ECKSCHLAGER, T.; KIZEK, R.

Vydáno

1. 12. 2012

ISSN

0360-2532

Periodikum

DRUG METABOLISM REVIEWS

Ročník

44

Číslo

4

Stát

Spojené státy americké

Strany od

287

Strany do

301

Strany počet

15

BibTex

@article{BUT144330,
  author="Soňa {Křížková} and Markéta {Vaculovičová} and Jan {Hraběta} and Vojtěch {Adam} and Marie {Stiborová} and Tomáš {Eckschlager} and René {Kizek}",
  title="Metallothioneins and zinc in cancer diagnosis and therapy",
  journal="DRUG METABOLISM REVIEWS",
  year="2012",
  volume="44",
  number="4",
  pages="287--301",
  doi="10.3109/03602532.2012.725414",
  issn="0360-2532"
}