Publication detail

Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review

POHANKA, M. MARTINKOVÁ, P. BRTNICKÝ, M. KYNICKÝ, J.

Original Title

Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review

Type

journal article in Web of Science

Language

English

Original Abstract

Sulfur mustard, in a chemical name bis(2-chloroethyl) sulfide, is a chemical warfare agent. It is cytotoxic and blister forming once spread over the skin. Though exact molecular mechanism of sulfur mustard toxic action remains unknown, inflammation and oxidative stress development are considered as the most relevant pathological consequences. Applications of either low-molecular weight antioxidants or cofactors for enzymatic antioxidants are considered as suitable ways how to ameliorate the poisoning. In this article, survey of literature on countermeasures against sulfur mustard poisoning are given and evidence of oxidative stress role during sulfur mustard poisoning and availability of antioxidants for the therapy are discussed.

Keywords

Oxidative stress; mustard gas; sulfur mustard; inflammation; poly(ADP-ribose) polymerase; antioxidant; bis(2-chloroethyl)sulfide

Authors

POHANKA, M.; MARTINKOVÁ, P.; BRTNICKÝ, M.; KYNICKÝ, J.

Released

1. 1. 2017

ISBN

1537-6516

Periodical

Toxicology Mechanisms and Methods

Year of study

27

Number

6

State

United States of America

Pages from

408

Pages to

416

Pages count

9

BibTex

@article{BUT145842,
  author="Miroslav {Pohanka} and Pavla {Martinková} and Martin {Brtnický} and Jindřich {Kynický}",
  title="Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review",
  journal="Toxicology Mechanisms and Methods",
  year="2017",
  volume="27",
  number="6",
  pages="408--416",
  doi="10.1080/15376516.2017.1320695",
  issn="1537-6516"
}