Detail publikace

Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review

POHANKA, M. MARTINKOVÁ, P. BRTNICKÝ, M. KYNICKÝ, J.

Originální název

Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Sulfur mustard, in a chemical name bis(2-chloroethyl) sulfide, is a chemical warfare agent. It is cytotoxic and blister forming once spread over the skin. Though exact molecular mechanism of sulfur mustard toxic action remains unknown, inflammation and oxidative stress development are considered as the most relevant pathological consequences. Applications of either low-molecular weight antioxidants or cofactors for enzymatic antioxidants are considered as suitable ways how to ameliorate the poisoning. In this article, survey of literature on countermeasures against sulfur mustard poisoning are given and evidence of oxidative stress role during sulfur mustard poisoning and availability of antioxidants for the therapy are discussed.

Klíčová slova

Oxidative stress; mustard gas; sulfur mustard; inflammation; poly(ADP-ribose) polymerase; antioxidant; bis(2-chloroethyl)sulfide

Autoři

POHANKA, M.; MARTINKOVÁ, P.; BRTNICKÝ, M.; KYNICKÝ, J.

Vydáno

1. 1. 2017

ISSN

1537-6516

Periodikum

Toxicology Mechanisms and Methods

Ročník

27

Číslo

6

Stát

Spojené státy americké

Strany od

408

Strany do

416

Strany počet

9

BibTex

@article{BUT145842,
  author="Miroslav {Pohanka} and Pavla {Martinková} and Martin {Brtnický} and Jindřich {Kynický}",
  title="Changes in the oxidative stress/anti-oxidant system after exposure to sulfur mustard and antioxidant strategies in the therapy, a review",
  journal="Toxicology Mechanisms and Methods",
  year="2017",
  volume="27",
  number="6",
  pages="408--416",
  doi="10.1080/15376516.2017.1320695",
  issn="1537-6516"
}