Publication detail

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

KYNICKÝ, J. MILOSAVLJEVIĆ, V. JELÍNKOVÁ, P. HADDAD, Y. MERLOS RODRIGO, M. BUCHTELOVÁ, H. BÝTEŠNÍKOVÁ, Z. BRTNICKÝ, M. RICHTERA, L. KOPEL, P. ADAM, V.

Original Title

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

Type

journal article in Web of Science

Language

English

Original Abstract

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against P. aeruginosa and S. typhimurium, where IC50 down to 125.9 and/or 36.1 A mu M were found for P. aeruginosa and S. typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be developed into highly effective antibacterial drug.

Keywords

Schiff base; Europium; Terbium; Cell penetrating peptide; Antimicrobial agents

Authors

KYNICKÝ, J.; MILOSAVLJEVIĆ, V.; JELÍNKOVÁ, P.; HADDAD, Y.; MERLOS RODRIGO, M.; BUCHTELOVÁ, H.; BÝTEŠNÍKOVÁ, Z.; BRTNICKÝ, M.; RICHTERA, L.; KOPEL, P.; ADAM, V.

Released

13. 6. 2018

ISBN

0366-6352

Periodical

Chemical Papers

Year of study

72

Number

6

State

Slovak Republic

Pages from

1437

Pages to

1449

Pages count

13

BibTex

@article{BUT148221,
  author="Jindřich {Kynický} and Vedran {Milosavljević} and Pavlína {Jelínková} and Yazan Abdulmajeed Eyadh {Haddad} and Miguel Ángel {Merlos Rodrigo} and Hana {Michálková} and Zuzana {Bytešníková} and Martin {Brtnický} and Lukáš {Richtera} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa",
  journal="Chemical Papers",
  year="2018",
  volume="72",
  number="6",
  pages="1437--1449",
  doi="10.1007/s11696-018-0400-3",
  issn="0366-6352"
}