Detail publikace

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

KYNICKÝ, J. MILOSAVLJEVIĆ, V. JELÍNKOVÁ, P. HADDAD, Y. MERLOS RODRIGO, M. BUCHTELOVÁ, H. BÝTEŠNÍKOVÁ, Z. BRTNICKÝ, M. RICHTERA, L. KOPEL, P. ADAM, V.

Originální název

Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Eu(III) and Tb(III) Schiff base complexes are applicable in various fields such as sensing, assays, screening protocols in vitro, and imaging studies in vitro or in vivo. Fluorescent europium and terbium complexes and their interaction with cell penetrating peptide (KKKRKC) can represent an excellent key for understanding pathway of peptide transportation though cell membrane and the application of Schiff base complexes as potential antibacterial drugs. The Schiff base-metal complexes and its conjugates with peptide were tested for their antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium. Schiff base-metal complexes conjugated with peptide show minor toxicity in normal human PNT1A cells and high antibacterial activity against P. aeruginosa and S. typhimurium, where IC50 down to 125.9 and/or 36.1 A mu M were found for P. aeruginosa and S. typhimurium, respectively. Our results strongly suggest that Schiff base-metal complexes conjugated with peptide have great potential to be developed into highly effective antibacterial drug.

Klíčová slova

Schiff base; Europium; Terbium; Cell penetrating peptide; Antimicrobial agents

Autoři

KYNICKÝ, J.; MILOSAVLJEVIĆ, V.; JELÍNKOVÁ, P.; HADDAD, Y.; MERLOS RODRIGO, M.; BUCHTELOVÁ, H.; BÝTEŠNÍKOVÁ, Z.; BRTNICKÝ, M.; RICHTERA, L.; KOPEL, P.; ADAM, V.

Vydáno

13. 6. 2018

ISSN

0366-6352

Periodikum

Chemical Papers

Ročník

72

Číslo

6

Stát

Slovenská republika

Strany od

1437

Strany do

1449

Strany počet

13

BibTex

@article{BUT148221,
  author="Jindřich {Kynický} and Vedran {Milosavljević} and Pavlína {Jelínková} and Yazan Abdulmajeed Eyadh {Haddad} and Miguel Ángel {Merlos Rodrigo} and Hana {Michálková} and Zuzana {Bytešníková} and Martin {Brtnický} and Lukáš {Richtera} and Pavel {Kopel} and Vojtěch {Adam}",
  title="Europium and terbium Schiff base peptide complexes as potential antimicrobial agents against Salmonella typhimurium and Pseudomonas aeruginosa",
  journal="Chemical Papers",
  year="2018",
  volume="72",
  number="6",
  pages="1437--1449",
  doi="10.1007/s11696-018-0400-3",
  issn="0366-6352"
}