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LAFFLEUR, F. KROUSKÁ, J. TKACZ, J. PEKAŘ, M. AGHAI, F. NETSOMBOON, K.
Original Title
Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?
Type
journal article in Web of Science
Language
English
Original Abstract
This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.
Keywords
Allantoin, buccal, cellulose, film, mucoadhesion.
Authors
LAFFLEUR, F.; KROUSKÁ, J.; TKACZ, J.; PEKAŘ, M.; AGHAI, F.; NETSOMBOON, K.
Released
25. 10. 2018
ISBN
0378-5173
Periodical
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Year of study
1-2
Number
550
State
Kingdom of the Netherlands
Pages from
309
Pages to
315
Pages count
7
URL
https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005
BibTex
@article{BUT149262, author="LAFFLEUR, F. and KROUSKÁ, J. and TKACZ, J. and PEKAŘ, M. and AGHAI, F. and NETSOMBOON, K.", title="Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?", journal="INTERNATIONAL JOURNAL OF PHARMACEUTICS", year="2018", volume="1-2", number="550", pages="309--315", doi="10.1016/j.ijpharm.2018.08.032", issn="0378-5173", url="https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005" }