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LAFFLEUR, F. KROUSKÁ, J. TKACZ, J. PEKAŘ, M. AGHAI, F. NETSOMBOON, K.
Originální název
Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
This study was undertaken to prepare films by solvent evaporation method comprising well-known polymers in order to investigate their potential for buccal suitability. Mucoadhesive films were manufactured using different polymers such as ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose as well as carboxymethyl cellulose. Buccal films were evaluated in regards of mucoadhesiveness, swelling and physico-chemical properties. Furthermore rheological measurement and adhesion study were carried out on the buccal porcine mucosa. Moreover, allantoin as humectant was incorporated and trans-mucosal water loss was determined. The results showed that physico-chemical, buccal adhesive and swelling properties varied depending on the composition of the polymers. The findings indicated films containing allantoin to be suitable for buccal application. In completion, adhesive films are appropriate and promising formulations in the treatment of various disease in the intraoral cavity.
Klíčová slova
Allantoin, buccal, cellulose, film, mucoadhesion.
Autoři
LAFFLEUR, F.; KROUSKÁ, J.; TKACZ, J.; PEKAŘ, M.; AGHAI, F.; NETSOMBOON, K.
Vydáno
25. 10. 2018
ISSN
0378-5173
Periodikum
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Ročník
1-2
Číslo
550
Stát
Nizozemsko
Strany od
309
Strany do
315
Strany počet
7
URL
https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005
BibTex
@article{BUT149262, author="LAFFLEUR, F. and KROUSKÁ, J. and TKACZ, J. and PEKAŘ, M. and AGHAI, F. and NETSOMBOON, K.", title="Buccal adhesive films with moisturizer- the next level for dry mouth syndrome?", journal="INTERNATIONAL JOURNAL OF PHARMACEUTICS", year="2018", volume="1-2", number="550", pages="309--315", doi="10.1016/j.ijpharm.2018.08.032", issn="0378-5173", url="https://www.sciencedirect.com/science/article/pii/S0378517318306033#f0005" }