Přístupnostní navigace
E-application
Search Search Close
Publication detail
NEČAS, A. PROKS, P. URBANOVÁ, L. SRNEC, R. STEHLÍK, L. CRHA, M. RAUŠER, P. PLÁNKA, L. JANOVEC, J. DVOŘÁK, M. AMLER, E. VOJTOVÁ, L. JANČÁŘ, J.
Original Title
Healing of Large Segmental Bone Defect after Implantation of Autogenous Cancellous Bone Graft in Comparison to Hydroxyapatite and 0.5% Collagen Scaffold Combined with Mesenchymal Stem Cells
Type
journal article - other
Language
English
Original Abstract
At present, attention is focused on research into possibilities of healing large bone defects by the method of mini-invasive osteosynthesis, using implantation of biomaterials and mesenchymal stem cells (MSCs). This study evaluates the healing of segmental femoral defects in miniature pigs based on the radiological determination of the callus: cortex ratio at 16 weeks after ostectomy. The size of the formed callus was significantly larger (p < 0.05) in animals after transplantation of an autogenous cancellous bone graft (group A, callus : cortex ratio of 1.77 ± 0.33) compared to animals after transplantation of cylindrical scaffold from hydroxyapatite and 0.5% collagen (group S, callus : cortex ratio of 1.08 ± 0.13), or in animals after transplantation of this scaffold seeded with MSCs (group S + MSCs, callus: cortex ratio of 1.15 ± 0.18). No significant difference was found in the size of callus between animals of group S and animals of group S + MSCs. Unlike a scaffold in the shape of the original bone column, a freely placed autogenous cancellous bone graft may allow the newly formed tissue to spread more to the periphery of the ostectomy defect. Implanted cylindrical scaffolds (with and without MSCs) support callus formation directly in the center of original bone column in segmental femoral ostectomy, and can be successfully used in the treatment of large bone defects.
Keywords
Fracture fixation, bone healing, comminuted fracture, callus, ostectomy, buttress plate
Authors
NEČAS, A.; PROKS, P.; URBANOVÁ, L.; SRNEC, R.; STEHLÍK, L.; CRHA, M.; RAUŠER, P.; PLÁNKA, L.; JANOVEC, J.; DVOŘÁK, M.; AMLER, E.; VOJTOVÁ, L.; JANČÁŘ, J.
Released
6. 4. 2010
Publisher
University of Veterinary and Pharmaceutical Sciences in Brno
Location
Brno, Czech Republic
ISBN
0001-7213
Periodical
ACTA VETERINARIA BRNO
Year of study
79
Number
4
State
Czech Republic
Pages from
607
Pages to
613
Pages count
7
URL
https://actavet.vfu.cz/79/4/0607/
Full text in the Digital Library
http://hdl.handle.net/11012/85286
BibTex
@article{BUT149675, author="NEČAS, A. and PROKS, P. and URBANOVÁ, L. and SRNEC, R. and STEHLÍK, L. and CRHA, M. and RAUŠER, P. and PLÁNKA, L. and JANOVEC, J. and DVOŘÁK, M. and AMLER, E. and VOJTOVÁ, L. and JANČÁŘ, J.", title="Healing of Large Segmental Bone Defect after Implantation of Autogenous Cancellous Bone Graft in Comparison to Hydroxyapatite and 0.5% Collagen Scaffold Combined with Mesenchymal Stem Cells", journal="ACTA VETERINARIA BRNO", year="2010", volume="79", number="4", pages="607--613", doi="10.2754/avb201079040607", issn="0001-7213", url="https://actavet.vfu.cz/79/4/0607/" }