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NEČAS, A. PROKS, P. URBANOVÁ, L. SRNEC, R. STEHLÍK, L. CRHA, M. RAUŠER, P. PLÁNKA, L. JANOVEC, J. DVOŘÁK, M. AMLER, E. VOJTOVÁ, L. JANČÁŘ, J.
Originální název
Healing of Large Segmental Bone Defect after Implantation of Autogenous Cancellous Bone Graft in Comparison to Hydroxyapatite and 0.5% Collagen Scaffold Combined with Mesenchymal Stem Cells
Typ
článek v časopise - ostatní, Jost
Jazyk
angličtina
Originální abstrakt
At present, attention is focused on research into possibilities of healing large bone defects by the method of mini-invasive osteosynthesis, using implantation of biomaterials and mesenchymal stem cells (MSCs). This study evaluates the healing of segmental femoral defects in miniature pigs based on the radiological determination of the callus: cortex ratio at 16 weeks after ostectomy. The size of the formed callus was significantly larger (p < 0.05) in animals after transplantation of an autogenous cancellous bone graft (group A, callus : cortex ratio of 1.77 ± 0.33) compared to animals after transplantation of cylindrical scaffold from hydroxyapatite and 0.5% collagen (group S, callus : cortex ratio of 1.08 ± 0.13), or in animals after transplantation of this scaffold seeded with MSCs (group S + MSCs, callus: cortex ratio of 1.15 ± 0.18). No significant difference was found in the size of callus between animals of group S and animals of group S + MSCs. Unlike a scaffold in the shape of the original bone column, a freely placed autogenous cancellous bone graft may allow the newly formed tissue to spread more to the periphery of the ostectomy defect. Implanted cylindrical scaffolds (with and without MSCs) support callus formation directly in the center of original bone column in segmental femoral ostectomy, and can be successfully used in the treatment of large bone defects.
Klíčová slova
Fracture fixation, bone healing, comminuted fracture, callus, ostectomy, buttress plate
Autoři
NEČAS, A.; PROKS, P.; URBANOVÁ, L.; SRNEC, R.; STEHLÍK, L.; CRHA, M.; RAUŠER, P.; PLÁNKA, L.; JANOVEC, J.; DVOŘÁK, M.; AMLER, E.; VOJTOVÁ, L.; JANČÁŘ, J.
Vydáno
6. 4. 2010
Nakladatel
University of Veterinary and Pharmaceutical Sciences in Brno
Místo
Brno, Czech Republic
ISSN
0001-7213
Periodikum
ACTA VETERINARIA BRNO
Ročník
79
Číslo
4
Stát
Česká republika
Strany od
607
Strany do
613
Strany počet
7
URL
https://actavet.vfu.cz/79/4/0607/
Plný text v Digitální knihovně
http://hdl.handle.net/11012/85286
BibTex
@article{BUT149675, author="NEČAS, A. and PROKS, P. and URBANOVÁ, L. and SRNEC, R. and STEHLÍK, L. and CRHA, M. and RAUŠER, P. and PLÁNKA, L. and JANOVEC, J. and DVOŘÁK, M. and AMLER, E. and VOJTOVÁ, L. and JANČÁŘ, J.", title="Healing of Large Segmental Bone Defect after Implantation of Autogenous Cancellous Bone Graft in Comparison to Hydroxyapatite and 0.5% Collagen Scaffold Combined with Mesenchymal Stem Cells", journal="ACTA VETERINARIA BRNO", year="2010", volume="79", number="4", pages="607--613", doi="10.2754/avb201079040607", issn="0001-7213", url="https://actavet.vfu.cz/79/4/0607/" }