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KARGEROVÁ, A. PEKAŘ, M.
Original Title
Ultrasonic study of hyaluronan interactions with Septonex – a pharmaceutical cationic surfactant
Type
journal article in Web of Science
Language
English
Original Abstract
Interactions between hyaluronan and the cationic surfactant Septonex were studied using high resolution ultrasound spectroscopy. Four different interaction regions were identified in aqueous solution in a narrow interval of surfactant concentrations. In contrast, in 0.15 mol/L NaCl solution, essentially only two principal regions were observed. Hyaluronan-Septonex aggregates were generally less compressible than Septonex monomers or micelles and their formation in water was not appreciably affected by hyaluronan molecular weight. In the presence of NaCl, the effect of hyaluronan molecular weight was more profound, which can be ascribed to its conformational sensitivity to ionic strength combined with its role as a surfactant counterion. Hyaluronan-Septonex interactions were closer to interactions with CTAB than with TTAB. Differences in structure or Krafft temperature (solubility) between Septonex and CTAB were thus not significantly reflected in these interactions. The basic characteristics of Septonex surfactant were also determined.
Keywords
hyaluronan; Septonex; ultrasonic velocity; compressibility; surfactant
Authors
KARGEROVÁ, A.; PEKAŘ, M.
Released
1. 1. 2019
ISBN
0144-8617
Periodical
Carbohydrate Polymers
Year of study
204
Number
1
State
United Kingdom of Great Britain and Northern Ireland
Pages from
17
Pages to
23
Pages count
7
URL
https://doi.org/10.1016/j.carbpol.2018.09.077
BibTex
@article{BUT150480, author="Andrea {Hurčíková} and Miloslav {Pekař}", title="Ultrasonic study of hyaluronan interactions with Septonex – a pharmaceutical cationic surfactant", journal="Carbohydrate Polymers", year="2019", volume="204", number="1", pages="17--23", doi="10.1016/j.carbpol.2018.09.077", issn="0144-8617", url="https://doi.org/10.1016/j.carbpol.2018.09.077" }