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ŠŤASTNÁ, E. ČÁSTKOVÁ, K.
Original Title
Electrospinning and biocompatibility of polymer-ceramic nanofibers for tissue engineering
Type
conference paper
Language
English
Original Abstract
Polycaprolactone is known as biocompatible material for long time and it is considered as possible material for bioscaffolds. Since natural structure of hard tissues (bones) and most of soft tissues (skin, neural tissue) is fibrous, there are attempts to mimic such a structure. Polycaprolactone (PCL) nanofibers with diameter of approximately 180 nm were prepared by electrospinning method. For better biocompatibility and bioactivity, a composite fibrous structure was prepared. Hydroxyapatite nanoparticles were synthetized via precipitation reaction and further hydrothermal treatment. The ceramic particles were added to modified polycaprolactone precursor and the solution was electrospun. The prepared fibers and as well as dried original precursor were in-vitro tested for cytotoxicity by direct contact test. Mouse fibroblast from L929 line were used for cell cultivation. It was found out that fibrous structure and presence of ceramic particles have a positive influence on cell activity and proliferation – the growth rate of the cells was significantly higher compared to bulk polymer precursor.
Keywords
Nanofibers, electrospinning, biocompatibility, polycaprolactone
Authors
ŠŤASTNÁ, E.; ČÁSTKOVÁ, K.
Released
1. 1. 2019
ISBN
978-80-87294-89-5
Book
10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))
Pages from
472
Pages to
476
Pages count
5
BibTex
@inproceedings{BUT153362, author="Eva {Šťastná} and Klára {Částková}", title="Electrospinning and biocompatibility of polymer-ceramic nanofibers for tissue engineering", booktitle="10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))", year="2019", pages="472--476", isbn="978-80-87294-89-5" }