Publication detail

Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery

VILLA, K. KREJČOVÁ, L. NOVOTNÝ, F. HEGER, Z. SOFER, Z. PUMERA, M.

Original Title

Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery

Type

journal article in Web of Science

Language

English

Original Abstract

Autonomous self-propelled micromachines, taking energy from surrounding environment and converting it to their motion, are on the forefront of the research for smart materials in the recent years. Owing to their self-propulsion mechanism, they have demonstrated to be more efficient drug carriers than passive particles. Here, multifunctional superparamagnetic/catalytic microrobots (PM/Pt microrobots) for cell manipulation, anticancer drug loading, and delivery to breast cancer cells are presented. These PM/Pt microrobots are fabricated from superparamagnetic polymer particles with iron oxide in their interior and an external tosylated surface, which is half-covered by a catalytic platinum (Pt) layer. This result in a triple-functionality-tosyl group-rich polymer layer can bind molecules and biological materials, Pt layer can catalyze decomposition of hydrogen peroxide, providing propulsion to the microrobots and magnetic part allows for manipulation by magnetic field. PM/Pt microrobots are able to move as individual robots and to team-up under influence of weak magnetic field by forming chains of the micromachines to perform collective actions, such as capture and transportation of cancer cells. The efficacy of PM/Pt microrobots to perform several tasks without complex surface functionalization steps simplifies the applicability of such multifunctional devices toward diverse biomedical applications.

Keywords

biomedical applications; cell manipulation; drug delivery; magnetic control; micromotors

Authors

VILLA, K.; KREJČOVÁ, L.; NOVOTNÝ, F.; HEGER, Z.; SOFER, Z.; PUMERA, M.

Released

24. 10. 2018

ISBN

1616-301X

Periodical

ADVANCED FUNCTIONAL MATERIALS

Year of study

28

Number

43

State

Federal Republic of Germany

Pages from

1

Pages to

8

Pages count

8

BibTex

@article{BUT156199,
  author="Katherine {Villa} and Ludmila {Krejčová} and Filip {Novotný} and Zbyněk {Heger} and Zdeněk {Sofer} and Martin {Pumera}",
  title="Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery",
  journal="ADVANCED FUNCTIONAL MATERIALS",
  year="2018",
  volume="28",
  number="43",
  pages="1--8",
  doi="10.1002/adfm.201804343",
  issn="1616-301X"
}