Detail publikace

Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery

VILLA, K. KREJČOVÁ, L. NOVOTNÝ, F. HEGER, Z. SOFER, Z. PUMERA, M.

Originální název

Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Autonomous self-propelled micromachines, taking energy from surrounding environment and converting it to their motion, are on the forefront of the research for smart materials in the recent years. Owing to their self-propulsion mechanism, they have demonstrated to be more efficient drug carriers than passive particles. Here, multifunctional superparamagnetic/catalytic microrobots (PM/Pt microrobots) for cell manipulation, anticancer drug loading, and delivery to breast cancer cells are presented. These PM/Pt microrobots are fabricated from superparamagnetic polymer particles with iron oxide in their interior and an external tosylated surface, which is half-covered by a catalytic platinum (Pt) layer. This result in a triple-functionality-tosyl group-rich polymer layer can bind molecules and biological materials, Pt layer can catalyze decomposition of hydrogen peroxide, providing propulsion to the microrobots and magnetic part allows for manipulation by magnetic field. PM/Pt microrobots are able to move as individual robots and to team-up under influence of weak magnetic field by forming chains of the micromachines to perform collective actions, such as capture and transportation of cancer cells. The efficacy of PM/Pt microrobots to perform several tasks without complex surface functionalization steps simplifies the applicability of such multifunctional devices toward diverse biomedical applications.

Klíčová slova

biomedical applications; cell manipulation; drug delivery; magnetic control; micromotors

Autoři

VILLA, K.; KREJČOVÁ, L.; NOVOTNÝ, F.; HEGER, Z.; SOFER, Z.; PUMERA, M.

Vydáno

24. 10. 2018

ISSN

1616-301X

Periodikum

ADVANCED FUNCTIONAL MATERIALS

Ročník

28

Číslo

43

Stát

Spolková republika Německo

Strany od

1

Strany do

8

Strany počet

8

BibTex

@article{BUT156199,
  author="Katherine {Villa} and Ludmila {Krejčová} and Filip {Novotný} and Zbyněk {Heger} and Zdeněk {Sofer} and Martin {Pumera}",
  title="Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery",
  journal="ADVANCED FUNCTIONAL MATERIALS",
  year="2018",
  volume="28",
  number="43",
  pages="1--8",
  doi="10.1002/adfm.201804343",
  issn="1616-301X"
}