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KALINA, M. KARGEROVÁ, A. PEKAŘ, M.
Original Title
DEAE-dextran hydrochloride behaviour in aqueous solution—The effect of ionic strength and concentration
Type
journal article in Web of Science
Language
English
Original Abstract
DEAE-dextran hydrochloride is a positively charged biocompatible polyelectrolyte. Its behaviour in aqueous solutions – the changes in its colloidal characteristics and resulting conformation changes – were investigated using a combination of light scattering, densitometry and ultrasound spectrometry. The results indicated the formation of a voluminous, hydrated and coiled conformation of chains having average particle sizes in the range of units of microns at low ionic strength. This phenomenon was supported by an increase in DEAE-dextran hydrochloride concentration in the solution. The increase in ionic strength caused the shielding of DEAE-dextran hydrochloride charges on its chain, resulting in the destabilization of the conformation arrangement of the polyelectrolyte and the formation of denser, more compact and stiffer structures having smaller particle sizes. The proposed model of DEAE-dextran hydrochloride density in the studied environments (distilled water, NaCl solutions) showed the possibility of using a single equation model to calculate the overall density of the system.
Keywords
DEAE-dextran hydrochloride; conformation; ionic strength; polyelectrolyte; density model
Authors
KALINA, M.; KARGEROVÁ, A.; PEKAŘ, M.
Released
15. 9. 2019
Publisher
Elsevier Ltd.
Location
Oxford, England
ISBN
0144-8617
Periodical
Carbohydrate Polymers
Number
220
State
United Kingdom of Great Britain and Northern Ireland
Pages from
163
Pages to
169
Pages count
7
URL
https://doi.org/10.1016/j.carbpol.2019.05.070
BibTex
@article{BUT157110, author="Michal {Kalina} and Andrea {Hurčíková} and Miloslav {Pekař}", title="DEAE-dextran hydrochloride behaviour in aqueous solution—The effect of ionic strength and concentration", journal="Carbohydrate Polymers", year="2019", number="220", pages="163--169", doi="10.1016/j.carbpol.2019.05.070", issn="0144-8617", url="https://doi.org/10.1016/j.carbpol.2019.05.070" }