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KAUCKÁ, M. TESAŘOVÁ, M. ZIKMUND, T. KAISER, J. ADAMEYKO, I.
Original Title
Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage
Type
presentation, poster
Language
English
Original Abstract
Control of shape and size during growth of the mammalian face is highly enigmatic. Complexly shaped cartilage structures in developing face provide a great model system to tackle this question. We investigated major principles of facial cartilage induction and scaling up. We found that basic 3D-blueprint of facial cartilages is induced as early mesenchymal condensations by combinatorial signals derived from epithelia and nervous system. We also revealed that the final shape and size of every solid cartilage structure in the embryonic head are achieved through two processes going in parallel: incremental addition of adjacently-induced chondrogenic condensations combined with scaling up of the pre-laid cartilage. The scaling is accomplished through a previously unknown mechanism of growth based on introducing oriented clonal units into existing cartilage from the perichondral cell layer. We took advantage of various molecular tools to demonstrate how specific clonal dynamics in cartilage enables uncoupling lateral expansion from thickness control as well as geometrical fine-tuning.
Keywords
Conference poster
Authors
KAUCKÁ, M.; TESAŘOVÁ, M.; ZIKMUND, T.; KAISER, J.; ADAMEYKO, I.
Released
3. 6. 2019
Publisher
WILEY
ISBN
0362-2525
Periodical
JOURNAL OF MORPHOLOGY
Year of study
280
State
United States of America
Pages from
200
Pages to
201
Pages count
244
URL
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003
BibTex
@misc{BUT157896, author="Markéta {Kaucká} and Markéta {Kaiser} and Tomáš {Zikmund} and Jozef {Kaiser} and Igor {Adameyko}", title="Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage", year="2019", journal="JOURNAL OF MORPHOLOGY", volume="280", pages="200--201", publisher="WILEY", issn="0362-2525", url="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003", note="presentation, poster" }