Detail publikace

Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

KAUCKÁ, M. TESAŘOVÁ, M. ZIKMUND, T. KAISER, J. ADAMEYKO, I.

Originální název

Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage

Typ

prezentace, poster

Jazyk

angličtina

Originální abstrakt

Control of shape and size during growth of the mammalian face is highly enigmatic. Complexly shaped cartilage structures in developing face provide a great model system to tackle this question. We investigated major principles of facial cartilage induction and scaling up. We found that basic 3D-blueprint of facial cartilages is induced as early mesenchymal condensations by combinatorial signals derived from epithelia and nervous system. We also revealed that the final shape and size of every solid cartilage structure in the embryonic head are achieved through two processes going in parallel: incremental addition of adjacently-induced chondrogenic condensations combined with scaling up of the pre-laid cartilage. The scaling is accomplished through a previously unknown mechanism of growth based on introducing oriented clonal units into existing cartilage from the perichondral cell layer. We took advantage of various molecular tools to demonstrate how specific clonal dynamics in cartilage enables uncoupling lateral expansion from thickness control as well as geometrical fine-tuning.

Klíčová slova

Conference poster

Autoři

KAUCKÁ, M.; TESAŘOVÁ, M.; ZIKMUND, T.; KAISER, J.; ADAMEYKO, I.

Vydáno

3. 6. 2019

Nakladatel

WILEY

ISSN

0362-2525

Periodikum

JOURNAL OF MORPHOLOGY

Ročník

280

Stát

Spojené státy americké

Strany od

200

Strany do

201

Strany počet

244

URL

https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003

BibTex

@misc{BUT157896,
  author="Markéta {Kaucká} and Markéta {Kaiser} and Tomáš {Zikmund} and Jozef {Kaiser} and Igor {Adameyko}",
  title="Oriented Clonal Cell Dynamics Enables Accurate Growth and Shaping of Mammalian Facial Cartilage",
  year="2019",
  journal="JOURNAL OF MORPHOLOGY",
  volume="280",
  pages="200--201",
  publisher="WILEY",
  issn="0362-2525",
  url="https://onlinelibrary.wiley.com/doi/abs/10.1002/jmor.21003",
  note="presentation, poster"
}