Publication detail

Unexpected therapeutic effects of cisplatin

RAUDENSKÁ, M. BALVAN, J. FOJTŮ, M. GUMULEC, J. MASAŘÍK, M.

Original Title

Unexpected therapeutic effects of cisplatin

Type

journal article in Web of Science

Language

English

Original Abstract

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.

Keywords

cisplatin; alternative effects of cisplatin

Authors

RAUDENSKÁ, M.; BALVAN, J.; FOJTŮ, M.; GUMULEC, J.; MASAŘÍK, M.

Released

1. 7. 2019

ISBN

1756-5901

Periodical

METALLOMICS

Year of study

11

Number

7

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1182

Pages to

1199

Pages count

18

URL

https://pubs.rsc.org/en/content/articlelanding/2019/MT/C9MT00049F#!divAbstract

BibTex

@article{BUT163400,
  author="Martina {Raudenská} and Jan {Balvan} and Michaela {Fojtů} and Jaromír {Gumulec} and Michal {Masařík}",
  title="Unexpected therapeutic effects of cisplatin",
  journal="METALLOMICS",
  year="2019",
  volume="11",
  number="7",
  pages="1182--1199",
  doi="10.1039/c9mt00049f",
  issn="1756-5901",
  url="https://pubs.rsc.org/en/content/articlelanding/2019/MT/C9MT00049F#!divAbstract"
}