Detail publikace

Unexpected therapeutic effects of cisplatin

RAUDENSKÁ, M. BALVAN, J. FOJTŮ, M. GUMULEC, J. MASAŘÍK, M.

Originální název

Unexpected therapeutic effects of cisplatin

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and metastatic testicular cancers. It is generally accepted that the major mechanism of cisplatin anti-cancer action is DNA damage. However, cisplatin is also effective in metastatic cancers and should, therefore, affect slow-cycling cancer stem cells in some way. In this review, we focused on the alternative effects of cisplatin that can support a good therapeutic response. First, attention was paid to the effects of cisplatin at the cellular level such as changes in intracellular pH and cellular mechanical properties. Alternative cellular targets of cisplatin, and the effects of cisplatin on cancer cell metabolism and ER stress were also discussed. Furthermore, the impacts of cisplatin on the tumor microenvironment and in the whole organism context were reviewed. In this review, we try to reveal possible causes of the unexpected effectiveness of this anti-cancer drug.

Klíčová slova

cisplatin; alternative effects of cisplatin

Autoři

RAUDENSKÁ, M.; BALVAN, J.; FOJTŮ, M.; GUMULEC, J.; MASAŘÍK, M.

Vydáno

1. 7. 2019

ISSN

1756-5901

Periodikum

METALLOMICS

Ročník

11

Číslo

7

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1182

Strany do

1199

Strany počet

18

URL

https://pubs.rsc.org/en/content/articlelanding/2019/MT/C9MT00049F#!divAbstract

BibTex

@article{BUT163400,
  author="Martina {Raudenská} and Jan {Balvan} and Michaela {Fojtů} and Jaromír {Gumulec} and Michal {Masařík}",
  title="Unexpected therapeutic effects of cisplatin",
  journal="METALLOMICS",
  year="2019",
  volume="11",
  number="7",
  pages="1182--1199",
  doi="10.1039/c9mt00049f",
  issn="1756-5901",
  url="https://pubs.rsc.org/en/content/articlelanding/2019/MT/C9MT00049F#!divAbstract"
}