Publication detail

Preventing the cytotoxic effects of tyrosine kinase inhibitors on healthy breast cells through loading into the ferritin nanocages

ŠKUBALOVÁ, Z. REX, S. SÚKUPOVÁ, M. SKLÁDAL, P. PŘIBYL, J. MICHÁLKOVÁ, H. ADAM, V. HEGER, Z.

Original Title

Preventing the cytotoxic effects of tyrosine kinase inhibitors on healthy breast cells through loading into the ferritin nanocages

Type

abstract

Language

English

Original Abstract

This study is focused on the antiproliferative effects of tyrosine kinase inhibitors (TKIs) loaded into the protein cage ferritin. Since many TKIs show high cytotoxicity not only towards their target, cancer cells, but also towards healthy surrounding tissue, the prevention of these adverse effects is of utmost importance. Development of nanocarriers with loaded active agents has been proven to help minimize this off-target cytotoxicity. It is also very suitable for poorly water soluble pharmaceuticals.

Keywords

cytotoxic effect; tyrosine kinase inhibitors; breast cells; ferritin nanocages

Authors

ŠKUBALOVÁ, Z.; REX, S.; SÚKUPOVÁ, M.; SKLÁDAL, P.; PŘIBYL, J.; MICHÁLKOVÁ, H.; ADAM, V.; HEGER, Z.

Released

5. 9. 2020

ISBN

1337-6853

Periodical

Interdisciplinary Toxicology

Year of study

13

Number

1

State

Federal Republic of Germany

Pages from

70

Pages to

70

Pages count

1

BibTex

@misc{BUT166219,
  author="Zuzana {Škubalová} and Simona {Rex} and Martina {Súkupová} and Petr {Skládal} and Jan {Přibyl} and Hana {Michálková} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Preventing the cytotoxic effects of tyrosine kinase inhibitors on healthy breast cells through loading into the ferritin nanocages",
  booktitle="Interdisciplinary toxicology TOXCON 2020: Programme & Abstracts",
  year="2020",
  journal="Interdisciplinary Toxicology",
  volume="13",
  number="1",
  pages="70--70",
  issn="1337-6853",
  note="abstract"
}