Detail publikace

Preventing the cytotoxic effects of tyrosine kinase inhibitors on healthy breast cells through loading into the ferritin nanocages

ŠKUBALOVÁ, Z. REX, S. SÚKUPOVÁ, M. SKLÁDAL, P. PŘIBYL, J. MICHÁLKOVÁ, H. ADAM, V. HEGER, Z.

Originální název

Preventing the cytotoxic effects of tyrosine kinase inhibitors on healthy breast cells through loading into the ferritin nanocages

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

This study is focused on the antiproliferative effects of tyrosine kinase inhibitors (TKIs) loaded into the protein cage ferritin. Since many TKIs show high cytotoxicity not only towards their target, cancer cells, but also towards healthy surrounding tissue, the prevention of these adverse effects is of utmost importance. Development of nanocarriers with loaded active agents has been proven to help minimize this off-target cytotoxicity. It is also very suitable for poorly water soluble pharmaceuticals.

Klíčová slova

cytotoxic effect; tyrosine kinase inhibitors; breast cells; ferritin nanocages

Autoři

ŠKUBALOVÁ, Z.; REX, S.; SÚKUPOVÁ, M.; SKLÁDAL, P.; PŘIBYL, J.; MICHÁLKOVÁ, H.; ADAM, V.; HEGER, Z.

Vydáno

5. 9. 2020

ISSN

1337-6853

Periodikum

Interdisciplinary Toxicology

Ročník

13

Číslo

1

Stát

Spolková republika Německo

Strany od

70

Strany do

70

Strany počet

1

BibTex

@misc{BUT166219,
  author="Zuzana {Škubalová} and Simona {Rex} and Martina {Súkupová} and Petr {Skládal} and Jan {Přibyl} and Hana {Michálková} and Vojtěch {Adam} and Zbyněk {Heger}",
  title="Preventing the cytotoxic effects of tyrosine kinase inhibitors on healthy breast cells through loading into the ferritin nanocages",
  booktitle="Interdisciplinary toxicology TOXCON 2020: Programme & Abstracts",
  year="2020",
  journal="Interdisciplinary Toxicology",
  volume="13",
  number="1",
  pages="70--70",
  issn="1337-6853",
  note="abstract"
}