Publication detail

Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

VILLA, K. VIKTOROVÁ, J. PLUTNAR, J. RUML, T. HOANG, L. PUMERA, M.

Original Title

Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

Type

journal article - other

Language

English

Original Abstract

Mouths offer the perfect environments for microbial cell formation, promoting the growth of biofilms, for example, on teeth. Dental biofilm exhibits strong resistance to antibiotics and is a cause of many dental diseases. Common strategies for dental biofilm removal involve the addition of high concentrations of hydrogen peroxide (H2O2), which increases tooth sensitivity, or mechanical procedures. Here, we report a different approach based on self-propelled micromachines with high antibacterial activity for the degradation of dental biofilm. Such microrobots use low concentrations of fuel for their propulsion, and they achieve an efficient dental biofilm disruption in only 5 min of treatment. Moreover, these microrobots are biocompatible with epidermal and organ cells and may stimulate the immune system to fight against microbial infection. This approach of exploiting the active motion of bubble-propelled catalytic micromachines for oral biofilm disruption may open the door for more efficient and sophisticated treatments in dentistry.

Keywords

micromotors;bubble propulsion;hydroxyl radicals;dental biofilm;titanium dioxide;antibacterial activity;biofilm disruption;gum treatment

Authors

VILLA, K.; VIKTOROVÁ, J.; PLUTNAR, J.; RUML, T.; HOANG, L.; PUMERA, M.

Released

23. 9. 2020

Publisher

Cell Press

ISBN

2666-3864

Periodical

Cell Reports Physical Science

Year of study

1

Number

9

State

United States of America

Pages from

1

Pages to

18

Pages count

18

URL

https://www.sciencedirect.com/science/article/pii/S2666386420301922

Full text in the Digital Library

http://hdl.handle.net/11012/195857

BibTex

@article{BUT167681,
  author="Katherine {Villa} and Jitka {Viktorová} and Jan {Plutnar} and Tomáš {Ruml} and Lan {Hoang} and Martin {Pumera}",
  title="Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm",
  journal="Cell Reports Physical Science",
  year="2020",
  volume="1",
  number="9",
  pages="1--18",
  doi="10.1016/j.xcrp.2020.100181",
  issn="2666-3864",
  url="https://www.sciencedirect.com/science/article/pii/S2666386420301922"
}