Publication detail

TNF-alpha can induce lymphocyte apoptosis during experimentally induced mastitis caused by lipopolysaccharide

SLÁMA, P. KABOURKOVÁ, E. PAVLÍK, A.

Original Title

TNF-alpha can induce lymphocyte apoptosis during experimentally induced mastitis caused by lipopolysaccharide

Type

abstract

Language

English

Original Abstract

The aim of this study was to determine whether lymphocyte apoptosis is modulated by infections caused by Staphylococcus aureus and Streptococcus uberis. Samples of cell populations were obtained by lavage of the mammary glands at 4 intervals (24,48, 72 and 168 h) following infection. The percentage of apoptotic lymphocytes peaked at 168 h after challenge with S. aureus or S. uberis. Subsequent experiments focused on in vitro cultivation of mammary gland lymphocytes with S. aureus and S. uberis. These experiments showed a lower percentage of apoptotic lymphocytes following 3 h of cultivating cells with bacteria than after cultivation without bacteria. The results demonstrate that during both experimental infection of bovine mammary glands with S. aureus or S. uberis and during in vitro cultivation of lymphocytes with S. aureus or S. uberis, apoptosis of lymphocytes is delayed

Keywords

STIMULATION

Authors

SLÁMA, P.; KABOURKOVÁ, E.; PAVLÍK, A.

Released

17. 10. 2017

ISBN

1365-3083

Periodical

Scandinavian Journal of Immunology

Year of study

86

Number

4

State

United Kingdom of Great Britain and Northern Ireland

Pages from

286

Pages to

286

Pages count

1

BibTex

@misc{BUT170242,
  author="Petr {Sláma} and Eliška {Kabourková} and Aleš {Pavlík}",
  title="TNF-alpha can induce lymphocyte apoptosis during experimentally induced mastitis caused by lipopolysaccharide",
  year="2017",
  journal="Scandinavian Journal of Immunology",
  volume="86",
  number="4",
  pages="286--286",
  issn="1365-3083",
  note="abstract"
}