Publication detail

Glycine-N-methyltransferase and Malignant Diseases of the Prostate

HEGER, Z. ECKSCHLAGER, T. STIBOROVÁ, M. ADAM, V.

Original Title

Glycine-N-methyltransferase and Malignant Diseases of the Prostate

Type

journal article in Scopus

Language

English

Original Abstract

Background: Prostate cancer (PC) constitutes a heterogeneous group of diseases with high prevalence rates that are still increasing, particularly in western countries. Since 1980, prostate specific antigen (PSA) and other diagnostic approaches have been used for PC screening; however, some of these approaches are often deemed painful and cause invasive damage of tissue. Therefore, molecular approaches to PC diagnosis are attracting increasing attention, potentially providing patients with less stressful situations and providing better diagnoses and even prognostic information. Recent metabolomic and genomic studies have suggested that biomolecules can be used as diagnostic or prognostic markers or as targets for the development of novel therapeutic modalities. One of these molecules is glycine-N-methyltransferase (GNMT), an enzyme that plays'a pivotal role in the biochemical conversion of glycine to sarcosine. The link between this molecule (encoded by homonymous gene - GNMT) and PC has been confirmed at several levels, and thus GNMT can be considered a promising target for the development of advanced diagnostic and/or prognostic approaches. Aim: The aim of this study was to analyse the physiological role of GNMT and to examine in greater detail its connection with PC at different levels, including gene structure, gene expression, and metabolism, in which GNMT plays an important role, not only in controlling the methylation status of cells, but also the metabolism of folic acid and methionine. Last but not least, we discuss the importance of cellular methylation processes and the link between their aberrations and PC development.

Keywords

Glycine N-Methyltransferase | Sarcosines | L-Pipecolate Dehydrogenase

Authors

HEGER, Z.; ECKSCHLAGER, T.; STIBOROVÁ, M.; ADAM, V.

Released

1. 1. 2016

ISBN

0862-495X

Periodical

Klinicka Onkologie

Year of study

29

Number

5

State

Czech Republic

Pages from

331

Pages to

335

Pages count

5

URL

https://www.linkos.cz/english-summary/klinicka-onkologie-journal/2016-10-15-5-en/glycine-n-methyltransferase-and-malignant-diseases-of-the-prostate/

BibTex

@article{BUT170405,
  author="Zbyněk {Heger} and Tomáš {Eckschlager} and Marie {Stiborová} and Vojtěch {Adam}",
  title="Glycine-N-methyltransferase and Malignant Diseases of the Prostate",
  journal="Klinicka Onkologie",
  year="2016",
  volume="29",
  number="5",
  pages="331--335",
  doi="10.14735/amko2016331",
  issn="0862-495X",
  url="https://www.linkos.cz/english-summary/klinicka-onkologie-journal/2016-10-15-5-en/glycine-n-methyltransferase-and-malignant-diseases-of-the-prostate/"
}