Detail publikace

Glycine-N-methyltransferase and Malignant Diseases of the Prostate

HEGER, Z. ECKSCHLAGER, T. STIBOROVÁ, M. ADAM, V.

Originální název

Glycine-N-methyltransferase and Malignant Diseases of the Prostate

Typ

článek v časopise ve Scopus, Jsc

Jazyk

angličtina

Originální abstrakt

Background: Prostate cancer (PC) constitutes a heterogeneous group of diseases with high prevalence rates that are still increasing, particularly in western countries. Since 1980, prostate specific antigen (PSA) and other diagnostic approaches have been used for PC screening; however, some of these approaches are often deemed painful and cause invasive damage of tissue. Therefore, molecular approaches to PC diagnosis are attracting increasing attention, potentially providing patients with less stressful situations and providing better diagnoses and even prognostic information. Recent metabolomic and genomic studies have suggested that biomolecules can be used as diagnostic or prognostic markers or as targets for the development of novel therapeutic modalities. One of these molecules is glycine-N-methyltransferase (GNMT), an enzyme that plays'a pivotal role in the biochemical conversion of glycine to sarcosine. The link between this molecule (encoded by homonymous gene - GNMT) and PC has been confirmed at several levels, and thus GNMT can be considered a promising target for the development of advanced diagnostic and/or prognostic approaches. Aim: The aim of this study was to analyse the physiological role of GNMT and to examine in greater detail its connection with PC at different levels, including gene structure, gene expression, and metabolism, in which GNMT plays an important role, not only in controlling the methylation status of cells, but also the metabolism of folic acid and methionine. Last but not least, we discuss the importance of cellular methylation processes and the link between their aberrations and PC development.

Klíčová slova

Glycine N-Methyltransferase | Sarcosines | L-Pipecolate Dehydrogenase

Autoři

HEGER, Z.; ECKSCHLAGER, T.; STIBOROVÁ, M.; ADAM, V.

Vydáno

1. 1. 2016

ISSN

0862-495X

Periodikum

Klinicka Onkologie

Ročník

29

Číslo

5

Stát

Česká republika

Strany od

331

Strany do

335

Strany počet

5

URL

https://www.linkos.cz/english-summary/klinicka-onkologie-journal/2016-10-15-5-en/glycine-n-methyltransferase-and-malignant-diseases-of-the-prostate/

BibTex

@article{BUT170405,
  author="Zbyněk {Heger} and Tomáš {Eckschlager} and Marie {Stiborová} and Vojtěch {Adam}",
  title="Glycine-N-methyltransferase and Malignant Diseases of the Prostate",
  journal="Klinicka Onkologie",
  year="2016",
  volume="29",
  number="5",
  pages="331--335",
  doi="10.14735/amko2016331",
  issn="0862-495X",
  url="https://www.linkos.cz/english-summary/klinicka-onkologie-journal/2016-10-15-5-en/glycine-n-methyltransferase-and-malignant-diseases-of-the-prostate/"
}