Publication detail

Decreased immune response after PASylation of stealth ferritin nanocarriers

TESAŘOVÁ, B. POLANSKÁ, H. ŠMÍDOVÁ, V. GOLIÁŠOVÁ, Z.

Original Title

Decreased immune response after PASylation of stealth ferritin nanocarriers

Type

conference paper

Language

English

Original Abstract

The effects on immunocompatibility after performed surface modifications (PEGylation and PASylation) of natural nanocarriers based on ferritin (FRT) were tested in this work. Potential cytostatic drug ellipticine (Elli) was encapsulated into FRT, leading to formation of FRTElli. The main goals of prepared PEG-FRTElli, PAS-10-FRTElli and PAS-20-FRTElli were to achieve decreased in vitro macrophage uptake and decreased in vivo complement activation. Macrophage uptake was studied via flow cytometry and complement activation via western blot. According to performed experiments PAS-10 modification was the only one that was sufficient to ensure both aspects.

Keywords

apoferritin; immune response; nanomedicine; PASylation

Authors

TESAŘOVÁ, B.; POLANSKÁ, H.; ŠMÍDOVÁ, V.; GOLIÁŠOVÁ, Z.

Released

7. 11. 2019

ISBN

978-80-7509-688-3

Book

MendelNet 2019: Proceedings of International PhD Students Conference

Pages from

671

Pages to

675

Pages count

5

URL

https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf

BibTex

@inproceedings{BUT170489,
  author="Barbora {Tesařová} and Hana {Polanská} and Veronika {Šmídová} and Zita {Goliášová}",
  title="Decreased immune response after PASylation of stealth ferritin nanocarriers",
  booktitle="MendelNet 2019: Proceedings of International PhD Students Conference",
  year="2019",
  pages="671--675",
  isbn="978-80-7509-688-3",
  url="https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf"
}