Detail publikace

Decreased immune response after PASylation of stealth ferritin nanocarriers

TESAŘOVÁ, B. POLANSKÁ, H. ŠMÍDOVÁ, V. GOLIÁŠOVÁ, Z.

Originální název

Decreased immune response after PASylation of stealth ferritin nanocarriers

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

The effects on immunocompatibility after performed surface modifications (PEGylation and PASylation) of natural nanocarriers based on ferritin (FRT) were tested in this work. Potential cytostatic drug ellipticine (Elli) was encapsulated into FRT, leading to formation of FRTElli. The main goals of prepared PEG-FRTElli, PAS-10-FRTElli and PAS-20-FRTElli were to achieve decreased in vitro macrophage uptake and decreased in vivo complement activation. Macrophage uptake was studied via flow cytometry and complement activation via western blot. According to performed experiments PAS-10 modification was the only one that was sufficient to ensure both aspects.

Klíčová slova

apoferritin; immune response; nanomedicine; PASylation

Autoři

TESAŘOVÁ, B.; POLANSKÁ, H.; ŠMÍDOVÁ, V.; GOLIÁŠOVÁ, Z.

Vydáno

7. 11. 2019

ISBN

978-80-7509-688-3

Kniha

MendelNet 2019: Proceedings of International PhD Students Conference

Strany od

671

Strany do

675

Strany počet

5

URL

https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf

BibTex

@inproceedings{BUT170489,
  author="Barbora {Tesařová} and Hana {Polanská} and Veronika {Šmídová} and Zita {Goliášová}",
  title="Decreased immune response after PASylation of stealth ferritin nanocarriers",
  booktitle="MendelNet 2019: Proceedings of International PhD Students Conference",
  year="2019",
  pages="671--675",
  isbn="978-80-7509-688-3",
  url="https://mnet.mendelu.cz/mendelnet2019/mnet_2019_full.pdf"
}