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BOHÁLOVÁ, N. CANTARA, A. BARTAS, M. KAURA, P. ŠŤASTNÝ, J. PEČINKA, P. FOJTA, M. MERGNY, J. BRÁZDA, V.
Original Title
Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection
Type
journal article in Web of Science
Language
English
Original Abstract
G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming sequences (PQS) in all viral genomes currently available in the NCBI database (including subviral agents). The G4Hunter algorithm was applied to a pool of 11,000 accessible viral genomes representing 350 Mbp in total. PQS frequencies differ across evolutionary groups of viruses, and are enriched in repeats, replication origins, 5′UTRs and 3′UTRs. Importantly, PQS presence and localization is connected to viral lifecycles and corresponds to the type of viral infection rather than to nucleic acid type; while viruses routinely causing persistent infections in Metazoa hosts are enriched for PQS, viruses causing acute infections are significantly depleted for PQS. The unique localization of PQS identifies the importance of G-quadruplex-based regulation of viral replication and life cycle, providing a tool for potential therapeutic targeting.
Keywords
Acute infection; Bioinformatics; G-quadruplex; G4Hunter; Persistent infection; Viral genome
Authors
BOHÁLOVÁ, N.; CANTARA, A.; BARTAS, M.; KAURA, P.; ŠŤASTNÝ, J.; PEČINKA, P.; FOJTA, M.; MERGNY, J.; BRÁZDA, V.
Released
1. 7. 2021
Publisher
Elsevier
ISBN
0300-9084
Periodical
BIOCHIMIE
Year of study
186
Number
1
State
French Republic
Pages from
13
Pages to
27
Pages count
15
URL
https://www.sciencedirect.com/science/article/pii/S0300908421000961
Full text in the Digital Library
http://hdl.handle.net/11012/200418
BibTex
@article{BUT171738, author="Natália {Bohálová} and Alessio {Cantara} and Martin {Bartas} and Patrik {Kaura} and Jiří {Šťastný} and Petr {Pečinka} and Miroslav {Fojta} and Jean-Louis {Mergny} and Václav {Brázda}", title="Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection", journal="BIOCHIMIE", year="2021", volume="186", number="1", pages="13--27", doi="10.1016/j.biochi.2021.03.017", issn="0300-9084", url="https://www.sciencedirect.com/science/article/pii/S0300908421000961" }