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BOHÁLOVÁ, N. CANTARA, A. BARTAS, M. KAURA, P. ŠŤASTNÝ, J. PEČINKA, P. FOJTA, M. MERGNY, J. BRÁZDA, V.
Originální název
Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming sequences (PQS) in all viral genomes currently available in the NCBI database (including subviral agents). The G4Hunter algorithm was applied to a pool of 11,000 accessible viral genomes representing 350 Mbp in total. PQS frequencies differ across evolutionary groups of viruses, and are enriched in repeats, replication origins, 5′UTRs and 3′UTRs. Importantly, PQS presence and localization is connected to viral lifecycles and corresponds to the type of viral infection rather than to nucleic acid type; while viruses routinely causing persistent infections in Metazoa hosts are enriched for PQS, viruses causing acute infections are significantly depleted for PQS. The unique localization of PQS identifies the importance of G-quadruplex-based regulation of viral replication and life cycle, providing a tool for potential therapeutic targeting.
Klíčová slova
Acute infection; Bioinformatics; G-quadruplex; G4Hunter; Persistent infection; Viral genome
Autoři
BOHÁLOVÁ, N.; CANTARA, A.; BARTAS, M.; KAURA, P.; ŠŤASTNÝ, J.; PEČINKA, P.; FOJTA, M.; MERGNY, J.; BRÁZDA, V.
Vydáno
1. 7. 2021
Nakladatel
Elsevier
ISSN
0300-9084
Periodikum
BIOCHIMIE
Ročník
186
Číslo
1
Stát
Francouzská republika
Strany od
13
Strany do
27
Strany počet
15
URL
https://www.sciencedirect.com/science/article/pii/S0300908421000961
Plný text v Digitální knihovně
http://hdl.handle.net/11012/200418
BibTex
@article{BUT171738, author="Natália {Bohálová} and Alessio {Cantara} and Martin {Bartas} and Patrik {Kaura} and Jiří {Šťastný} and Petr {Pečinka} and Miroslav {Fojta} and Jean-Louis {Mergny} and Václav {Brázda}", title="Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection", journal="BIOCHIMIE", year="2021", volume="186", number="1", pages="13--27", doi="10.1016/j.biochi.2021.03.017", issn="0300-9084", url="https://www.sciencedirect.com/science/article/pii/S0300908421000961" }