Publication detail

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

HAVLÍKOVÁ, M. JUGL, A. KROUSKÁ, J. SZABOVÁ, J.MRAVCOVÁ, L. VENEROVÁ, T. CHANG, C-H. PEKAŘ, M. MRAVEC, F.

Original Title

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

Type

journal article in Web of Science

Language

English

Original Abstract

High-resolution ultrasound spectroscopy (HR-US), size and zeta-potential titrations, and isothermal titration calorimetry (ITC) were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles composed of hexadecyltrimethylammonium-dodecylsulphate (HTMA-DS), dioctadecyldimethylammonium chloride (DODAC), and cholesterol. In addition to these methods, visual observations were performed with the selected molecular weight of hyaluronan. A very good correlation was obtained between data from size titration, HR-US, and visual observation, which indicated in lower charge ratios the formation of hyaluronan-coated vesicles. On the contrary, at higher charge ratios, coated vesicles disintegrated to a size of around 2000 nm. The intensity of these interactions and the disaggregation were dependent on the molecular weight of hyaluronan. All interactions studied by ITC showed strong exothermic behavior, and these interactions between vesicles and hyaluronan were confirmed from the first addition, independently of the molecular weight of hyaluronan.

Keywords

hyaluronan; ion pair amphiphile; dynamic light scattering; zeta potential; high-resolution ultrasonic spectroscopy; isothermal titration calorimetry

Authors

HAVLÍKOVÁ, M.; JUGL, A.; KROUSKÁ, J.; SZABOVÁ, J.;MRAVCOVÁ, L.; VENEROVÁ, T.; CHANG, C-H.; PEKAŘ, M.; MRAVEC, F.

Released

2. 6. 2021

Publisher

AMER CHEMICAL SOC

Location

WASHINGTON

ISBN

0743-7463

Periodical

Langmuir

Year of study

37

Number

28

State

United States of America

Pages from

8525

Pages to

8533

Pages count

9

URL

https://pubs-acs-org.ezproxy.lib.vutbr.cz/doi/abs/10.1021/acs.langmuir.1c00993

BibTex

@article{BUT171995,
  author="Martina {Havlíková} and Adam {Jugl} and Jitka {Krouská} and Jana {Szabová} and Ludmila {Mravcová} and Tereza {Venerová} and Chien-Hsiang {Chang} and Miloslav {Pekař} and Filip {Mravec}",
  title="Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study",
  journal="Langmuir",
  year="2021",
  volume="37",
  number="28",
  pages="8525--8533",
  doi="10.1021/acs.langmuir.1c00993",
  issn="0743-7463",
  url="https://pubs-acs-org.ezproxy.lib.vutbr.cz/doi/abs/10.1021/acs.langmuir.1c00993"
}