Detail publikace

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

HAVLÍKOVÁ, M. JUGL, A. KROUSKÁ, J. SZABOVÁ, J.MRAVCOVÁ, L. VENEROVÁ, T. CHANG, C-H. PEKAŘ, M. MRAVEC, F.

Originální název

Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

High-resolution ultrasound spectroscopy (HR-US), size and zeta-potential titrations, and isothermal titration calorimetry (ITC) were used to characterize the interactions between hyaluronan and catanionic ion pair amphiphile vesicles composed of hexadecyltrimethylammonium-dodecylsulphate (HTMA-DS), dioctadecyldimethylammonium chloride (DODAC), and cholesterol. In addition to these methods, visual observations were performed with the selected molecular weight of hyaluronan. A very good correlation was obtained between data from size titration, HR-US, and visual observation, which indicated in lower charge ratios the formation of hyaluronan-coated vesicles. On the contrary, at higher charge ratios, coated vesicles disintegrated to a size of around 2000 nm. The intensity of these interactions and the disaggregation were dependent on the molecular weight of hyaluronan. All interactions studied by ITC showed strong exothermic behavior, and these interactions between vesicles and hyaluronan were confirmed from the first addition, independently of the molecular weight of hyaluronan.

Klíčová slova

hyaluronan; ion pair amphiphile; dynamic light scattering; zeta potential; high-resolution ultrasonic spectroscopy; isothermal titration calorimetry

Autoři

HAVLÍKOVÁ, M.; JUGL, A.; KROUSKÁ, J.; SZABOVÁ, J.;MRAVCOVÁ, L.; VENEROVÁ, T.; CHANG, C-H.; PEKAŘ, M.; MRAVEC, F.

Vydáno

2. 6. 2021

Nakladatel

AMER CHEMICAL SOC

Místo

WASHINGTON

ISSN

0743-7463

Periodikum

Langmuir

Ročník

37

Číslo

28

Stát

Spojené státy americké

Strany od

8525

Strany do

8533

Strany počet

9

URL

https://pubs-acs-org.ezproxy.lib.vutbr.cz/doi/abs/10.1021/acs.langmuir.1c00993

BibTex

@article{BUT171995,
  author="Martina {Havlíková} and Adam {Jugl} and Jitka {Krouská} and Jana {Szabová} and Ludmila {Mravcová} and Tereza {Venerová} and Chien-Hsiang {Chang} and Miloslav {Pekař} and Filip {Mravec}",
  title="Interactions between Cationic Ion Pair Amphiphile Vesicles and Hyaluronan—A Physicochemical Study",
  journal="Langmuir",
  year="2021",
  volume="37",
  number="28",
  pages="8525--8533",
  doi="10.1021/acs.langmuir.1c00993",
  issn="0743-7463",
  url="https://pubs-acs-org.ezproxy.lib.vutbr.cz/doi/abs/10.1021/acs.langmuir.1c00993"
}