Publication detail

Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies

BALZEKAS, I. SLADKÝ, V. NEJEDLÝ, P. BRINKMANN, B. CREPEAU, D. MÍVALT, F. GREGG, N. ATTIA, T. MARKS, V. WHEELER, L. RICELLI, T. STAAB, J. LUNDSTROM, B. MILLER, K. VAN GOMPEL, J. KŘEMEN, V. CROARKIN, P. WORRELL, G.

Original Title

Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies

Type

journal article in Web of Science

Language

English

Original Abstract

Intracranial electroencephalographic (iEEG) recordings from patients with epilepsy provide distinct opportunities and novel data for the study of co-occurring psychiatric disorders. Comorbid psychiatric disorders are very common in drug-resistant epilepsy and their added complexity warrants careful consideration. In this review, we first discuss psychiatric comorbidities and symptoms in patients with epilepsy. We describe how epilepsy can potentially impact patient presentation and how these factors can be addressed in the experimental designs of studies focused on the electrophysiologic correlates of mood. Second, we review emerging technologies to integrate long-term iEEG recording with dense behavioral tracking in naturalistic environments. Third, we explore questions on how best to address the intersection between epilepsy and psychiatric comorbidities. Advances in ambulatory iEEG and long-term behavioral monitoring technologies will be instrumental in studying the intersection of seizures, epilepsy, psychiatric comorbidities, and their underlying circuitry.

Keywords

epilepsy; psychiatric disorders; major depression (MDD); SEEG (stereoelectroencephalography); electrocorticography (ECoG); deep brain stimulation; biomarker; neuromodulation

Authors

BALZEKAS, I.; SLADKÝ, V.; NEJEDLÝ, P.; BRINKMANN, B.; CREPEAU, D.; MÍVALT, F.; GREGG, N.; ATTIA, T.; MARKS, V.; WHEELER, L.; RICELLI, T.; STAAB, J.; LUNDSTROM, B.; MILLER, K.; VAN GOMPEL, J.; KŘEMEN, V.; CROARKIN, P.; WORRELL, G.

Released

26. 7. 2021

Publisher

Frontiers Media

Location

LAUSANNE

ISBN

1662-5161

Periodical

Frontiers in Human Neuroscience

Year of study

15

Number

1

State

Swiss Confederation

Pages from

1

Pages to

17

Pages count

17

URL

https://www.frontiersin.org/articles/10.3389/fnhum.2021.702605/full

Full text in the Digital Library

http://hdl.handle.net/11012/203033

BibTex

@article{BUT172290,
  author="Irena {Balzekas} and Vladimír {Sladký} and Petr {Nejedlý} and Benjamin H. {Brinkmann} and Daniel {Crepeau} and Filip {Mívalt} and Nicholas M. {Gregg} and Tal Pal {Attia} and Victoria S. {Marks} and Lydia P. {Wheeler} and Tori E. {Ricelli} and Jeffrey P. {Staab} and Brian {Lundstrom} and Kai J. {Miller} and Jamie J. {Van Gompel} and Václav {Křemen} and Paul E. {Croarkin} and Gregory {Worrell}",
  title="Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies",
  journal="Frontiers in Human Neuroscience",
  year="2021",
  volume="15",
  number="1",
  pages="1--17",
  doi="10.3389/fnhum.2021.702605",
  issn="1662-5161",
  url="https://www.frontiersin.org/articles/10.3389/fnhum.2021.702605/full"
}